CAJ | 학술논문

目的评估多系统萎缩(MSA)和帕金森病(PD)患者的呼吸功能.方法对临床诊断的16例MSA、20例PD患者及17例年龄、性别匹配的正常对照者行肺及呼吸肌功能测定.结果 MSA组较PD组肺一氧化碳弥散量(DLCO)占预测值百分比降低[(62.86±15.66)％比(76.67±18.98)％,P＜0.05].两组最大吸气压(MIP)占预测值百分比[MSA组(39.08±22.99)％、PD组(39.83±24.83)％比对照组(57.44±19.90)％,P＜0.05]、最大呼气压(MEP)占预测值百分比均较对照组均降低[MSA组(49.59±22.97)％、PD组(49.26±22.86)％比对照组(77.10±21.46)％,P＜0.001].结论临床相对常见神经系统变性病MSA和PD均存在呼吸功能受累,以呼吸力学功能障碍为著；MSA患者可能还存在肺换气功能障碍.应重视神经变性病患者呼吸功能.
목적 평고다계통위축(MSA)화파금삼병(PD)환자적호흡공능.방법 대림상진단적16례MSA、20례PD환자급17례년령、성별필배적정상대조자행폐급호흡기공능측정.결과 MSA조교PD조폐일양화탄미산량(DLCO)점예측치백분비강저[(62.86±15.66)％비(76.67±18.98)％,P＜0.05].량조최대흡기압(MIP)점예측치백분비[MSA조(39.08±22.99)％、PD조(39.83±24.83)％비대조조(57.44±19.90)％,P＜0.05]、최대호기압(MEP)점예측치백분비균교대조조균강저[MSA조(49.59±22.97)％、PD조(49.26±22.86)％비대조조(77.10±21.46)％,P＜0.001].결론 림상상대상견신경계통변성병MSA화PD균존재호흡공능수루,이호흡역학공능장애위저；MSA환자가능환존재폐환기공능장애.응중시신경변성병환자호흡공능.
Objective To investigate the characteristics of pulmonary function and respiratory muscle performance in patients with multiple system atrophy (MSA) and Parkinson's disease (PD).Methods Pulmonary function and respiratory muscle strength were evaluated in 16 MSA patients and 20 PD patients.Another 17 age and sex-matched healthy volunteers were recruited as controls.Results Carbon monoxide diffusion capacity (DLCO) was significantly decreased in MSA group compared with PD group [(62.86 ± 15.66)％ vs (76.67 ± 18.98)％,respectively,P ＜0.05].Maximal inspiration pressure (MIP) and maximal expiration pressure (MEP) were (39.08 ±22.99)％ and (49.59 ±22.97)％ in MSA group,(39.83 ± 24.83) ％ and (49.26 ± 22.86) ％ in PD group.Both MIP and MEP in MSA and PD groups were significantly reduced compared with controls [(57.44 ± 19.90) ％,P ＜ 0.05 ; (77.10 ± 21.46) ％,P ＜ 0.001].Conclusions Our findings suggest that respiratory dysfunction is involved in MSA and PD.The reduction of respiratory muscle strength is remarkable.The insufficiency of pulmonary diffusion function is more severe in MSA than in PD.More attention should be paid to the compromised respiratory function in neurodegenerative disorders.