CAJ | 학술논문

目的：探讨HGF和TGF-β1在非小细胞肺癌（ NSCLC）中的表达及临床意义。方法采用免疫组织化学方法检测73例非小细胞肺癌患者癌组织中及30例癌旁正常肺组织中HGF及TGF-β1的表达；分析HGF及TGF-β1表达情况及与临床病理参数之间的关系。结果73例肺癌组织中HGF的阳性表达率为67．1％，在30例癌旁正常组织的阳性表达率为16．7％，两者差异有显著性意义（ P＜0．05）；HGF的表达与肺癌淋巴结转移密切相关（P＜0．05），而与病理组织类型及肿瘤的分化程度无显著相关（P均＞0．05）。73例肺癌组织中TGF-β1的阳性表达率为49．3％，在30例癌旁正常肺组织的阳性表达率为16．7％，两者比较差异也有显著性意义（ P＜0．05）；TGF-β1的表达与肿瘤的分化程度、淋巴结转移密切相关（P均＜0．05），而与病理组织类型无显著相关（P＞0．05）。经Spearman相关分析， HGF与TGF-β1在NSCLC组织中的表达呈显著正相关（r＝0．340，P＜0．05）。结论在NSCLC中存在HGF与TGF-β1的高表达，两者的高表达可能促进了肿瘤的恶性增殖及淋巴结转移；联合检测HGF及TGF-β1对判断NSCLC恶性程度、转移潜能及预后有重要临床意义。
목적：탐토HGF화TGF-β1재비소세포폐암（ NSCLC）중적표체급림상의의。방법채용면역조직화학방법검측73례비소세포폐암환자암조직중급30례암방정상폐조직중HGF급TGF-β1적표체；분석HGF급TGF-β1표체정황급여림상병리삼수지간적관계。결과73례폐암조직중HGF적양성표체솔위67．1％，재30례암방정상조직적양성표체솔위16．7％，량자차이유현저성의의（ P＜0．05）；HGF적표체여폐암림파결전이밀절상관（P＜0．05），이여병리조직류형급종류적분화정도무현저상관（P균＞0．05）。73례폐암조직중TGF-β1적양성표체솔위49．3％，재30례암방정상폐조직적양성표체솔위16．7％，량자비교차이야유현저성의의（ P＜0．05）；TGF-β1적표체여종류적분화정도、림파결전이밀절상관（P균＜0．05），이여병리조직류형무현저상관（P＞0．05）。경Spearman상관분석， HGF여TGF-β1재NSCLC조직중적표체정현저정상관（r＝0．340，P＜0．05）。결론재NSCLC중존재HGF여TGF-β1적고표체，량자적고표체가능촉진료종류적악성증식급림파결전이；연합검측HGF급TGF-β1대판단NSCLC악성정도、전이잠능급예후유중요림상의의。
Objective To investigate the expression and clinicopathologic significance of hepatocyte growth factor ( HGF) and transforming growth factor -β1 (TGF-β1) in non-small cell lung cancer (NSCLC).Methods Applying the immu-nohistochemical technique , the expression of HGF and TGF -β1 in 73 patients with non -small cell lung cancer and 30 peri-cancerous normal lung tissue samples were determined .Relationships of expression of HGF and TGF -β1 with clini-copathologic features were analyzed .Results Of 73 patients with NSCLC, the positive expression rate of HGF was 67.1%, however, in 30 cases of peri-cancerous normal tissues , the positive expression rate of HGF was 16.7%,so expression of HGF in peri-cancerous normal tissues was significantly lower than in NSCLC tissues , there was statistical significance (P<0.05).Expression of HGF was significantly associated with lymphnode metastasis (P<0.05), while expression of HGF had no significant associated with tumor pathological types and degree of cell differentiation ( P>0 .05 ) .Of 73 pa-tients with lung cancer, the positive expression rate of TGF -β1 was 49.3%, in 30 cases of peri -cancerous normal tis-sues, the positive expression rate of TGF -β1 was 16.7%, so expression of TGF-β1 in peri-cancerous normal tissues was significantly lower than in NSCLC tissues, there was statistical significance(P<0.05).Expression of TGF -β1 was significantly associated with degree of cell differentiation and lymph node metastasis (P<0.05),while expression of TGF -β1 had no significant associated with tumor pathological types (P>0.05).By the analysis of Spearman correlation , the ex-pression of HGF was strongly positive correlated to TGF -β1 expression in lung cancer tissues (r=0.340,P<0.05). Conclusion Overexpression of HGF and TGF -β1 exists in lung cancer , expression of HGF and TGF-β1 were both asso-ciated with lymph node metastasis;this suggests that overexpression of HGF and TGF -β1 has important significance in an-alyzing the degree of malignancy ,the otential capacity of metastasis and prognosis .