长治医学院学报
長治醫學院學報
장치의학원학보
JOURNAL OF CHANGZHI MEDICAL COLLEGE
2014年
3期
178-180
,共3页
非小细胞肺癌%COX-2%CD44v6%免疫组织化学
非小細胞肺癌%COX-2%CD44v6%免疫組織化學
비소세포폐암%COX-2%CD44v6%면역조직화학
Non-small cell lung caner%COX-2%CD44v6%Immunohistochemistry
目的：探讨环氧化酶-2(COX-2)和粘附分子CD44变异型-6(CD44v6)在NSCLC中的表达及与淋巴结转移的关系。方法：应用免疫组化技术检测69例NSCLC中COX-2、CD44v6的表达。结果：(1) NSCLC中COX-2、CD44v6的阳性表达率分别为69.57%、72.46%,均显著高于正常肺组织(P <0.01)；(2)69例 NSCLC 中淋巴结转移33例,33例淋巴结转移组中 COX-2、CD44v6的阳性表达率分别为81.82%和84.85%,显著高于36例无淋巴结转移组(P <0.05)；(3)NSCLC 淋巴结转移组中 COX-2表达和CD44v6表达密切相关(P <0.05)。结论：COX-2和 CD44v6在 NSCLC 淋巴结转移过程中起重要作用,检测COX-2和CD44v6的表达可作为临床预测淋巴结转移和估计预后的重要指标。
目的：探討環氧化酶-2(COX-2)和粘附分子CD44變異型-6(CD44v6)在NSCLC中的錶達及與淋巴結轉移的關繫。方法：應用免疫組化技術檢測69例NSCLC中COX-2、CD44v6的錶達。結果：(1) NSCLC中COX-2、CD44v6的暘性錶達率分彆為69.57%、72.46%,均顯著高于正常肺組織(P <0.01)；(2)69例 NSCLC 中淋巴結轉移33例,33例淋巴結轉移組中 COX-2、CD44v6的暘性錶達率分彆為81.82%和84.85%,顯著高于36例無淋巴結轉移組(P <0.05)；(3)NSCLC 淋巴結轉移組中 COX-2錶達和CD44v6錶達密切相關(P <0.05)。結論：COX-2和 CD44v6在 NSCLC 淋巴結轉移過程中起重要作用,檢測COX-2和CD44v6的錶達可作為臨床預測淋巴結轉移和估計預後的重要指標。
목적：탐토배양화매-2(COX-2)화점부분자CD44변이형-6(CD44v6)재NSCLC중적표체급여림파결전이적관계。방법：응용면역조화기술검측69례NSCLC중COX-2、CD44v6적표체。결과：(1) NSCLC중COX-2、CD44v6적양성표체솔분별위69.57%、72.46%,균현저고우정상폐조직(P <0.01)；(2)69례 NSCLC 중림파결전이33례,33례림파결전이조중 COX-2、CD44v6적양성표체솔분별위81.82%화84.85%,현저고우36례무림파결전이조(P <0.05)；(3)NSCLC 림파결전이조중 COX-2표체화CD44v6표체밀절상관(P <0.05)。결론：COX-2화 CD44v6재 NSCLC 림파결전이과정중기중요작용,검측COX-2화CD44v6적표체가작위림상예측림파결전이화고계예후적중요지표。
Objective:To study the expression of COX-2、CD44v6 and their correlation with lymph node metastasis in NSCLC.Methods:The expression of COX-2 and CD44v6 in 69 cases human NSCLC was detected with immunohistochemical method.Results:(1)The positive expression rate of COX-2 and CD44v6 in NSCLC were 69.57% and 72.46%,respectively. They are significantly higher than the expression in normal lung tissue(P<0.01);(2)There are 33 cases with lymph node metastasis in 69 NSCLC cases,the positive expression rate of COX-2 and CD44v6 in NSCLC with lymph node metastasis are respectively 81.82% and 84.85%,all significantly higher than those of 36 cases without lymph node metastasis(P<0.05);(3)There is a positive correlation between COX-2 and CD44v6 in NSCLC with lymph node metastasis.Conclusion:COX-2 and CD44v6 may play important roles in the lymph node metastasis of NSCLC.COX-2 and CD44v6 may be useful markers for predicting the lymph node metastasis and prognosis of NSCLC.
