中国神经精神疾病杂志
中國神經精神疾病雜誌
중국신경정신질병잡지
CHINESE JOURNAL OF NERVOUS AND MENTAL DISEASES
2014年
4期
218-222
,共5页
王梅%邓红%邓伟%李涛%李名立%李娜%林鄞%任虹燕%黄朝华%李寅飞%雷威%韩媛媛
王梅%鄧紅%鄧偉%李濤%李名立%李娜%林鄞%任虹燕%黃朝華%李寅飛%雷威%韓媛媛
왕매%산홍%산위%리도%리명립%리나%림은%임홍연%황조화%리인비%뢰위%한원원
精神分裂症%家族性%散发性%首发%认知功能
精神分裂癥%傢族性%散髮性%首髮%認知功能
정신분렬증%가족성%산발성%수발%인지공능
Schizophrenia%Familial%Sporadic%First-episode%Cognitive function
目的：探讨首发家族性与散发性精神分裂症患者的认知功能差异。方法纳入首发精神分裂症患者127例，其中家族性患者40例，散发性患者87例；同时纳入96名正常对照。采用修订的韦氏成人智力测验中部分量表对所有受试者进行认知功能评估，阳性与阴性症状量表（positive and negative syndrome scale ， PANSS）评定患者症状的严重程度，并分析认知功能与精神症状的相关性。结果家族性组与散发性组患者PANSS总分[（91.51±14.07）vs.（87.23±16.37）]、阳性症状分[（25.89±6.70）vs.（23.72±6.04）]、阴性症状分[（18.19±6.43）vs.（19.07±8.01）]差异无统计学意义（P>0.05）；两患者组全智商量表分、言语智商量表分和操作智商量表分均低于对照组（均P<0.05），散发性组操作智商量表分低于家族性组（P<0.05）。散发性组患者操作智商与PANSS总分（r=-0.46，P﹥0.01）、阳性症状分（r=-0.41，P=0.01）及阴性症状分（r=-0.36，P=0.02）呈负相关；木块图形校正分与PANSS总分（r=-0.41，P=0.01）及阳性症状分（r=-0.54，P<0.01）呈负相关。而家族性组中无此相关关系（均P>0.05）。结论首发精神分裂患者在发病初期认知功能即存在显著损害，散发性患者在智力方面受损较重，其受损程度与临床症状严重程度相关，而家族性患者智力的损害则独立于临床症状。
目的：探討首髮傢族性與散髮性精神分裂癥患者的認知功能差異。方法納入首髮精神分裂癥患者127例，其中傢族性患者40例，散髮性患者87例；同時納入96名正常對照。採用脩訂的韋氏成人智力測驗中部分量錶對所有受試者進行認知功能評估，暘性與陰性癥狀量錶（positive and negative syndrome scale ， PANSS）評定患者癥狀的嚴重程度，併分析認知功能與精神癥狀的相關性。結果傢族性組與散髮性組患者PANSS總分[（91.51±14.07）vs.（87.23±16.37）]、暘性癥狀分[（25.89±6.70）vs.（23.72±6.04）]、陰性癥狀分[（18.19±6.43）vs.（19.07±8.01）]差異無統計學意義（P>0.05）；兩患者組全智商量錶分、言語智商量錶分和操作智商量錶分均低于對照組（均P<0.05），散髮性組操作智商量錶分低于傢族性組（P<0.05）。散髮性組患者操作智商與PANSS總分（r=-0.46，P﹥0.01）、暘性癥狀分（r=-0.41，P=0.01）及陰性癥狀分（r=-0.36，P=0.02）呈負相關；木塊圖形校正分與PANSS總分（r=-0.41，P=0.01）及暘性癥狀分（r=-0.54，P<0.01）呈負相關。而傢族性組中無此相關關繫（均P>0.05）。結論首髮精神分裂患者在髮病初期認知功能即存在顯著損害，散髮性患者在智力方麵受損較重，其受損程度與臨床癥狀嚴重程度相關，而傢族性患者智力的損害則獨立于臨床癥狀。
목적：탐토수발가족성여산발성정신분렬증환자적인지공능차이。방법납입수발정신분렬증환자127례，기중가족성환자40례，산발성환자87례；동시납입96명정상대조。채용수정적위씨성인지력측험중부분량표대소유수시자진행인지공능평고，양성여음성증상량표（positive and negative syndrome scale ， PANSS）평정환자증상적엄중정도，병분석인지공능여정신증상적상관성。결과가족성조여산발성조환자PANSS총분[（91.51±14.07）vs.（87.23±16.37）]、양성증상분[（25.89±6.70）vs.（23.72±6.04）]、음성증상분[（18.19±6.43）vs.（19.07±8.01）]차이무통계학의의（P>0.05）；량환자조전지상량표분、언어지상량표분화조작지상량표분균저우대조조（균P<0.05），산발성조조작지상량표분저우가족성조（P<0.05）。산발성조환자조작지상여PANSS총분（r=-0.46，P﹥0.01）、양성증상분（r=-0.41，P=0.01）급음성증상분（r=-0.36，P=0.02）정부상관；목괴도형교정분여PANSS총분（r=-0.41，P=0.01）급양성증상분（r=-0.54，P<0.01）정부상관。이가족성조중무차상관관계（균P>0.05）。결론수발정신분렬환자재발병초기인지공능즉존재현저손해，산발성환자재지력방면수손교중，기수손정도여림상증상엄중정도상관，이가족성환자지력적손해칙독립우림상증상。
Objective To investigate the difference in cognitive functions between first-episode schizophrenia pa-tients with and without family history. Methods One hundred twenty-seven patients with first-episode schizophrenia were recruited, including 40 patients with family history and 87 sporadic patients. Ninety-six matched normal subjects served as controls. Seven subscales of the Wechsler Adult Intelligence Scale-Revised in China (WAIS-RC) were used to assess the cognitive functions of all subjects. Positive and Negative Symptom Scale (PANSS) was used to assess patients ’ symptoms. The relationship between clinical symptoms and cognitive deficits was analyzed. Results There was no signifi-cant difference in the PANSS scores between familial patients and sporadic patients [(91.51±14.07) vs. (87.23±16.37), P>0.05]. The scores of full intelligence quotient (IQ), verbal IQ and operation IQ were lower in patient groups than in con-trol group (all P<0.05). The score of operation IQ was lower in sporadic patients than in familial patients (P<0.05). The scores of PANSS (r=-0.43, P=0.01), positive symptoms (r=-0.32, P=0.04) and negative symptoms (r=-0.38, P=0.02) were negatively correlated with operation IQ, and the scores of PANSS(r=-0.41,P=0.01) and positive symptoms(r=-0.54, P<0.01) were negatively correlated with block rectification scores in sporadic patient group but not in the familial patient group (all P>0.05). Conclusion The patients with schizophrenia have significant intelligence deficits in the early stages. Cognitive deficits are associated with the disease severity in sporadic patients while are independent of clinical symptoms in familial patients.
