CAJ | 학술논문

【目的】探讨肝细胞肝癌（HCC）并肝硬化患者手术治疗的疗效、安全性、并发症及预后。【方法】以2001年1月至2008年8月在本院进行手术治疗的57例HCC并肝硬化患者为对象。采用回顾性分析方法，对患者治疗前后的资料进行整理分析，统计患者的年生存情况以及采用单因素与多因素回归分析方法探讨患者的年生存率相关影响因素。【结果】手术治疗后患者的1年生存率为63．6％，2年生存率52．1％，3年生存率34．7％，5年生存率19．3％。术前child分级，术前血小板计数，术前甲胎蛋白（AFP）计量，肿瘤组织大小以及是否进行根治性切除术与患者预后具有相关性（ P ＜0．05）。患者术前child分级与是否进行根治性手术是独立危险因素（ P ＜0．05）。【结论】手术是根治 HCC合并肝硬化的理想方法，但术前应准确评估患者的肝功能储备以及术后积极的辅助治疗是提高患者生存率和生活质量的关键。
【목적】탐토간세포간암（HCC）병간경화환자수술치료적료효、안전성、병발증급예후。【방법】이2001년1월지2008년8월재본원진행수술치료적57례HCC병간경화환자위대상。채용회고성분석방법，대환자치료전후적자료진행정리분석，통계환자적년생존정황이급채용단인소여다인소회귀분석방법탐토환자적년생존솔상관영향인소。【결과】수술치료후환자적1년생존솔위63．6％，2년생존솔52．1％，3년생존솔34．7％，5년생존솔19．3％。술전child분급，술전혈소판계수，술전갑태단백（AFP）계량，종류조직대소이급시부진행근치성절제술여환자예후구유상관성（ P ＜0．05）。환자술전child분급여시부진행근치성수술시독립위험인소（ P ＜0．05）。【결론】수술시근치 HCC합병간경화적이상방법，단술전응준학평고환자적간공능저비이급술후적겁적보조치료시제고환자생존솔화생활질량적관건。
[Objective]To explore the efficacy ,safety ,complication and prognosis of surgical treatment of hepatocellular carcinoma(HCC) with liver cirrhosis .[Methods] Totally 57 HCC patients with liver cirrhosis undergoing surgical treatment in our hospital from Jan .2001 to Aug .2008 were enrolled in the study .A ret-rospective analysis method was used to analyze all data of patients before and after surgery .The year survival rate was calculated .Univariate and multivariate regression method was used to analyze the influencing factors of year survival rate of patients .[Results] The 1-year ,2-year ,3-year and 5-year survival rate of patients after surgery was 63 .6% ,52 .1% ,34 .7% and 19 .3% ,respectively .Preoperative child grading ,preoperative platelet count ,preoperative alpha-fetoprotein(AFP) measurement ,tumor size and whether radical resection or not were all correlated with the prognosis ( P<0 .05) .Preoperative child grading and whether radical surgery or not was an independent risk factor ( P <0 .05) .[Conclusion]Surgery is the ideal method of radical treat-ment of HCC with liver cirrhosis ,but accurate preoperative assessment of patients'liver functional reserve and postoperative active adjuvant therapy is the key to improve survival rate and quality life of the patients .