医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2014年
4期
646-648
,共3页
韩玲玲%张晓蕾%王玉霞%尚晓菁
韓玲玲%張曉蕾%王玉霞%尚曉菁
한령령%장효뢰%왕옥하%상효정
糖尿病 ,2型%颈动脉%白细胞介素6%C反应蛋白质
糖尿病 ,2型%頸動脈%白細胞介素6%C反應蛋白質
당뇨병 ,2형%경동맥%백세포개소6%C반응단백질
Diabetes Mellitus,Type 2%Carotid Arteries%Interleukin-6%C-Reactive Protein
【目的】探讨2型糖尿病（T2DM）患者颈动脉内膜-中层厚度（IMT）与白介素-6（IL-6）及血清超敏反应蛋白（hs-CRP）的关系。【方法】选取新确诊的T2DM患者201例，按IMT分为IMT增厚组（IMT＞0．9 mm）99例及IM T正常组（IM T＜0．9 mm ）102例，均采集空腹血标本，测定血清IL-6及hs-CRP。使用彩色多普勒测定各组受试者的颈动脉IM T。【结果】①在T2DM 受试者中，IM T增厚组IL-6及hs-CRP水平均显著高于IM T 正常组（ P ＜0．01）。②在IM T增厚组，IL-6及hs-CRP均与IM T呈正相关（ r分别为0．73和0．78，P＜0．01），在IM T正常组，IL-6及hs-CRP与IM T亦呈正相关（ r分别为0．62和0．59，P ＜0．01）；将 T2DM 患者作为一个整体， IL-6与hs-CRP也存在相关性（ r为0．66，P ＜0．01）。【结论】IL-6及hs-CRP与 T2DM 患者早期动脉粥样硬化有密切的关系。
【目的】探討2型糖尿病（T2DM）患者頸動脈內膜-中層厚度（IMT）與白介素-6（IL-6）及血清超敏反應蛋白（hs-CRP）的關繫。【方法】選取新確診的T2DM患者201例，按IMT分為IMT增厚組（IMT＞0．9 mm）99例及IM T正常組（IM T＜0．9 mm ）102例，均採集空腹血標本，測定血清IL-6及hs-CRP。使用綵色多普勒測定各組受試者的頸動脈IM T。【結果】①在T2DM 受試者中，IM T增厚組IL-6及hs-CRP水平均顯著高于IM T 正常組（ P ＜0．01）。②在IM T增厚組，IL-6及hs-CRP均與IM T呈正相關（ r分彆為0．73和0．78，P＜0．01），在IM T正常組，IL-6及hs-CRP與IM T亦呈正相關（ r分彆為0．62和0．59，P ＜0．01）；將 T2DM 患者作為一箇整體， IL-6與hs-CRP也存在相關性（ r為0．66，P ＜0．01）。【結論】IL-6及hs-CRP與 T2DM 患者早期動脈粥樣硬化有密切的關繫。
【목적】탐토2형당뇨병（T2DM）환자경동맥내막-중층후도（IMT）여백개소-6（IL-6）급혈청초민반응단백（hs-CRP）적관계。【방법】선취신학진적T2DM환자201례，안IMT분위IMT증후조（IMT＞0．9 mm）99례급IM T정상조（IM T＜0．9 mm ）102례，균채집공복혈표본，측정혈청IL-6급hs-CRP。사용채색다보륵측정각조수시자적경동맥IM T。【결과】①재T2DM 수시자중，IM T증후조IL-6급hs-CRP수평균현저고우IM T 정상조（ P ＜0．01）。②재IM T증후조，IL-6급hs-CRP균여IM T정정상관（ r분별위0．73화0．78，P＜0．01），재IM T정상조，IL-6급hs-CRP여IM T역정정상관（ r분별위0．62화0．59，P ＜0．01）；장 T2DM 환자작위일개정체， IL-6여hs-CRP야존재상관성（ r위0．66，P ＜0．01）。【결론】IL-6급hs-CRP여 T2DM 환자조기동맥죽양경화유밀절적관계。
[Objective]To explore the relationship of carotid intima-media thickness (IM T ) with serum inter-leukin-6(IL-6) and high-sensitive C-reactive protein(hs-CRP) in patients with type 2 diabetes mellitus(T2DM) .[Methods]Totally 201 patients with newly diagnosed T2DM were selected .According to carotid IMT ,all patients were divided into IMT increased group(IMT>0 .9mm ,n=99) and normal IMT group(IMT<0 .9mm ,n=102) . Fast blood samples were collected .Serum levels of IL-6 and hs-CRP were measured .Carotid IMT of the subjects in each group was detected by using color Doppler apparatus .[Results] Among T2DM subjects ,the levels of IL-6 and hs-CRP in IMT increased group were significantly higher than those in normal IMT group ( P < 0 .01) .In IMT increased group ,IL-6 and hs-CRP were positively correlated with IMT (r was 0 .73 and 0 .78 respectively ,P<0 .01) .In normal IM T group ,IL-6 and hs-CRP were also positively correlated with IM T (r was 0 .62 and 0 .59 respectively ,P <0 .01) .If T2DM patients were considered as the whole ,IL-6 was also related with hs-CRP(r was 0 .66 ,P <0 .01) .[Conclusion] IL-6 and hs-CRP are closely related with early atherosclerosis of T 2DM pa-tients .
