医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2014年
4期
644-645,648
,共3页
膀胱肿瘤/病理学%丙酮酸激酶
膀胱腫瘤/病理學%丙酮痠激酶
방광종류/병이학%병동산격매
Urinary Bladder Neoplasms/PA%Pyruvate Kinase
【目的】探讨肿瘤型M2丙酮酸激酶（TumortypeM2-pyruvatekinase，TUM2-PK）在膀胱癌中的表达及临床意义分析。【方法】采取2009年1月至2012年1月，221例膀胱癌患者和220例健康正常人的血清标本，应用酶联免疫吸附测定法（ELISA）定量检测标本的TUM2-PK水平，研究试验组与对照组，以及病理分型与TUM2-PK关系。【结果】膀胱癌患者血清中TUM2-PK的含量明显高于正常对照组[（39．4±3．5）u/mLvs（7．3±2．1）u/mL（P＜0．05）]；同时根据膀胱癌病理分级TUM2-PK的含量存在一定差异：T1期（32．1±6．1）u/mL，T2期（34．1±4．3）u/mL，T3期（68．2±5．9）u/mL。T1期膀胱癌与T2期膀胱癌TUM2-PK含量无明显差异，但T3期较T1、T2明显增高。【结论】监测血清中TUM2-PK含量有助于膀胱肿瘤的早期诊断，同时根据TUM2-PK的含量亦可作为监测肿瘤及疾病分级的重要手段之一。
【目的】探討腫瘤型M2丙酮痠激酶（TumortypeM2-pyruvatekinase，TUM2-PK）在膀胱癌中的錶達及臨床意義分析。【方法】採取2009年1月至2012年1月，221例膀胱癌患者和220例健康正常人的血清標本，應用酶聯免疫吸附測定法（ELISA）定量檢測標本的TUM2-PK水平，研究試驗組與對照組，以及病理分型與TUM2-PK關繫。【結果】膀胱癌患者血清中TUM2-PK的含量明顯高于正常對照組[（39．4±3．5）u/mLvs（7．3±2．1）u/mL（P＜0．05）]；同時根據膀胱癌病理分級TUM2-PK的含量存在一定差異：T1期（32．1±6．1）u/mL，T2期（34．1±4．3）u/mL，T3期（68．2±5．9）u/mL。T1期膀胱癌與T2期膀胱癌TUM2-PK含量無明顯差異，但T3期較T1、T2明顯增高。【結論】鑑測血清中TUM2-PK含量有助于膀胱腫瘤的早期診斷，同時根據TUM2-PK的含量亦可作為鑑測腫瘤及疾病分級的重要手段之一。
【목적】탐토종류형M2병동산격매（TumortypeM2-pyruvatekinase，TUM2-PK）재방광암중적표체급림상의의분석。【방법】채취2009년1월지2012년1월，221례방광암환자화220례건강정상인적혈청표본，응용매련면역흡부측정법（ELISA）정량검측표본적TUM2-PK수평，연구시험조여대조조，이급병리분형여TUM2-PK관계。【결과】방광암환자혈청중TUM2-PK적함량명현고우정상대조조[（39．4±3．5）u/mLvs（7．3±2．1）u/mL（P＜0．05）]；동시근거방광암병리분급TUM2-PK적함량존재일정차이：T1기（32．1±6．1）u/mL，T2기（34．1±4．3）u/mL，T3기（68．2±5．9）u/mL。T1기방광암여T2기방광암TUM2-PK함량무명현차이，단T3기교T1、T2명현증고。【결론】감측혈청중TUM2-PK함량유조우방광종류적조기진단，동시근거TUM2-PK적함량역가작위감측종류급질병분급적중요수단지일。
[Objective]To explore the expression of tumor type M2-pyruvate kinase(Tu M2-PK) in bladder cancer and its clinical significance .[Methods] Serum samples of 221 patients with bladder cancer and 220 healthy normal people from Jan .2009 to Jan .2012 were collected .Serum level of Tu M2-PK was detected by ELISA ,and compared between experimental group and control group .The correlation between Tu M2-PK and pathological type was analyzed .[Results]Serum levels of Tu M2-PK in patients with bladder cancer were ob-viously higher than those in control group[(39 .4 ± 3 .5)u/mL vs (7 .3 ± 2 .1)u/mL ,P <0 .05)] .There was significant difference in Tu M2-PK level among different pathological stages of bladder cancer .Tu M2-PK lev-els in stage T1 ,T2 and T3 were (32 .1 ± 6 .1)u/mL ,(34 .1 ± 4 .3)u/mL and (68 .2 ± 5 .9)u/mL ,respectively . There was no significant difference in Tu M2-PK level between stage T1 and stage T2 .Compared with stage T1 and T2 ,Tu M2-PK levels in stage T3 were increased obviously .[Conclusion] The monitoring of serum Tu M2-PK is helpful for the early diagnosis of bladder cancer .Meanwhile Tu M2-PK level can be also used as an important means for the monitoring and grading of the tumor .
