CAJ | 학술논문

【目的】探讨宫内缺氧对新生儿红细胞渗透脆性的影响。【方法】选择湘雅医院2012～2013年新生儿科27例无新生儿窒息的住院患儿，根据出生前有无缺氧病史将患儿分为对照组（ n ＝20）和宫内缺氧组（ n ＝7）。于生后1 h内抽取动脉血进行血气、乳酸（LA）和微量血胆红素（BIL）测定，生后24 h内抽取静脉血进行红细胞渗透脆性的测定。【结果】宫内缺氧组出生时 Apgar 评分，血液 pH 值，动脉二氧化碳分压（PaCO2）与对照组差异无显著性（ P＞0．05），但其动脉氧分压（PaO2）、动脉血样饱和度（SaO2）和微量血BIL明显低于对照组（ P ＜0．05～0．01），而血L A浓度明显高于对照组（ P ＜0．01）；当溶血率分别为20％、50％、80％和90％时，宫内缺氧组所需NaCl缓冲液浓度均明显低于对照组（ P ＜0．05～0．01），而当溶血率分别为10％和100％时，宫内缺氧组所需NaCl缓冲液浓度与对照组相比显差无异统计学意义（ P ＞0．05）。【结论】宫内缺氧可引起新生儿红细胞的渗透脆性降低。
【목적】탐토궁내결양대신생인홍세포삼투취성적영향。【방법】선택상아의원2012～2013년신생인과27례무신생인질식적주원환인，근거출생전유무결양병사장환인분위대조조（ n ＝20）화궁내결양조（ n ＝7）。우생후1 h내추취동맥혈진행혈기、유산（LA）화미량혈담홍소（BIL）측정，생후24 h내추취정맥혈진행홍세포삼투취성적측정。【결과】궁내결양조출생시 Apgar 평분，혈액 pH 치，동맥이양화탄분압（PaCO2）여대조조차이무현저성（ P＞0．05），단기동맥양분압（PaO2）、동맥혈양포화도（SaO2）화미량혈BIL명현저우대조조（ P ＜0．05～0．01），이혈L A농도명현고우대조조（ P ＜0．01）；당용혈솔분별위20％、50％、80％화90％시，궁내결양조소수NaCl완충액농도균명현저우대조조（ P ＜0．05～0．01），이당용혈솔분별위10％화100％시，궁내결양조소수NaCl완충액농도여대조조상비현차무이통계학의의（ P ＞0．05）。【결론】궁내결양가인기신생인홍세포적삼투취성강저。
[Objective]To explore the impact of intrauterine hypoxia on erythrocyte osmotic fragility in newbo-rns .[Methods]Totally 27 newborns without neonatal asphyxia in department of neonatology of Xiangya hospital from 2012~2013 were selected .According to the history of intrauterine hypoxia before birth ,all patients were divided into control group( n=20) and intrauterine hypoxia group ( n=7) .Arterial blood samples were extracted within 1h after birth to detect blood gas ,lactic acid(LA) and minimal bilirubin(BIL) .Venous blood was drawn within 24h to detect erythrocyte osmotic fragility .[Results]There was no significant difference in Apgar score ,pH and PaCO2 between in-trauterine hypoxia group and control group ( P>0 .05) .PaO2 ,SaO2 and minimal BIL in intrauterine hypoxia group were obviously lower than those in control group ( P<0 .01~0 .05) ,but LA level in intrauterine hypoxia group was obviously higher than that in control group ( P<0 .01) .When hemolysis ratio was 20% ,50% ,80% and 90% re-spectively ,NaCl buffer solution concentration in intrauterine hypoxia group was lower than that in control group ( P<0 .05~0 .01) .When hemolysis ratio was 10% and 100% respectively ,there was no difference in NaCl buffer solu-tion concentration between intrauterine hypoxia group and control group ( P>0 .05) .[Conclusion]Intrauterine hypox-ia can decrease erythrocyte osmotic fragility in newborns .