CAJ | 학술논문

目的　探讨天然珊瑚羟基磷灰石(HA)及仿HA生物陶瓷与角膜的生物相容性及愈合特性,以评价其作为人工角膜支架材料的可行性。。方法　　分别将天然珊瑚HA支架与相同规格的仿HA生物陶瓷支架植入碱烧伤后兔角膜板层,于不同时间裂隙灯观察并进行组织病理学检查?。结果　天然珊瑚HA组:6例植入物,均获得了良好的稳定性及安全性,观察期最长已达17个月,组织病理学检查亦证实其与角膜组织具有良好的生物相容性且不影响角膜组织的营养和代谢?仿HA生物陶瓷组:6例植入物在2个月内全部脱出,前板层角膜溶解、坏死。。结论　　　天然珊瑚HA与角膜组织具有良好的生物相容性,能与受体角膜生物愈合,可用作人工角膜支架
목적　탐토천연산호간기린회석(HA)급방HA생물도자여각막적생물상용성급유합특성,이평개기작위인공각막지가재료적가행성。。방법　　분별장천연산호HA지가여상동규격적방HA생물도자지가식입감소상후토각막판층,우불동시간렬극등관찰병진행조직병이학검사?。결과　천연산호HA조:6례식입물,균획득료량호적은정성급안전성,관찰기최장이체17개월,조직병이학검사역증실기여각막조직구유량호적생물상용성차불영향각막조직적영양화대사?방HA생물도자조:6례식입물재2개월내전부탈출,전판층각막용해、배사。。결론　　　천연산호HA여각막조직구유량호적생물상용성,능여수체각막생물유합,가용작인공각막지가
ObjectiveTo present a prospective experimental study of the new supporting material for keratoprosthesis(Kpro)porous genus coral hydroxyapatite(HA)and bionic porcelainiame.MethodThe discs of 8-mm-diameter,0.5-mm-thick,200-μm-pore diameter made of genus coral HA or bionic porcelain are implanted intralamellarly in eyes of New Zealand rabbits.ResultsThe genus coral implants which revealed fibrovascular tissue by pathologic studies were accepted by rabbit corneas,but all bionic porcelain implants were extruded in 2 months.ConclusionThe genus coral HA can be used as a support for a Kpro,which is highly bio-compatible,bio-integrable,non-biodegradable and is able to be colonized;otherwise,bionic porcelain should be further improved