CAJ | 학술논문

目的:观察中药益气散聚方对非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)患者的疗效.方法:将符合纳入标准的67例NAFLD患者,随机分为益气散聚方组39例和安慰剂对照组28例.分别予益气散聚方和安慰剂治疗3个月,观察治疗前后临床症状、肝脾CT比值、体质量指数(body mass index,BMI)、腰围、稳态模型胰岛素抵抗指数(homeostatic model assessment for insulin resistance,HOMA2-IR)、肝功能、肿瘤坏死因子a(tumor necrosis factor-α,TNF-α)、高敏C反应蛋白(high sensitivity C-reactiveprotein,hs-CRP)和血脂等方面的变化.结果:治疗后,益气散聚方组临床症状明显缓解,肝脾CT比值明显上升,BMI、HOMA2-IR水平下降,肝功能好转,TNF-α、hs-CRP和血脂水平明显下降,与安慰剂组相比,差异有统计学意义;益气散聚方组总有效率为94.87%.结论:中药益气散聚方治疗NAFLD疗效确切.
목적:관찰중약익기산취방대비주정성지방성간병(non-alcoholic fatty liver disease,NAFLD)환자적료효.방법:장부합납입표준적67례NAFLD환자,수궤분위익기산취방조39례화안위제대조조28례.분별여익기산취방화안위제치료3개월,관찰치료전후림상증상、간비CT비치、체질량지수(body mass index,BMI)、요위、은태모형이도소저항지수(homeostatic model assessment for insulin resistance,HOMA2-IR)、간공능、종류배사인자a(tumor necrosis factor-α,TNF-α)、고민C반응단백(high sensitivity C-reactiveprotein,hs-CRP)화혈지등방면적변화.결과:치료후,익기산취방조림상증상명현완해,간비CT비치명현상승,BMI、HOMA2-IR수평하강,간공능호전,TNF-α、hs-CRP화혈지수평명현하강,여안위제조상비,차이유통계학의의;익기산취방조총유효솔위94.87%.결론:중약익기산취방치료NAFLD료효학절.