CAJ | 학술논문

目前再生障碍性贫血常用的动物建模方法有物理、化学、物理化学、免疫介导方法.以上四种方法各有优缺点.该文从模型组动物临床表现、外周血全血细胞、网织红细胞计数、骨髓有核细胞计数、病理,淋巴细胞亚群和免疫功能等方面对以上四种方法进行综合分析,期望在综合常见造模方式优点的基础上,建立新的简单、有效、稳定的动物模型制备方法.
목전재생장애성빈혈상용적동물건모방법유물리、화학、물이화학、면역개도방법.이상사충방법각유우결점.해문종모형조동물림상표현、외주혈전혈세포、망직홍세포계수、골수유핵세포계수、병리,림파세포아군화면역공능등방면대이상사충방법진행종합분석,기망재종합상견조모방식우점적기출상,건립신적간단、유효、은정적동물모형제비방법.
Aplastic anemia (AA) animal models can be established by the methods such as physics,chemistry,physical chemistry,immunology and others.However,there are some disadvantages in these animal AA models.On the basis of clinical manifestations,peripheral blood cells,reticulocyte count,bone marrow nucleated cell count,pathology,lymphocyte subsets and immune function and other aspects from animal model,a comprehensive analysis of these four methods was taken,to find a new simple,effective and stable animal model of AA.