CAJ | 학술논문

目的探讨应用清热凉血法对大面积烧伤早期高凝状态(热毒血瘀型)的临床治疗作用.方法本研究分为对照组, 常规治疗组及中药治疗组.对照组为正常健康献血者;常规治疗组为大面积烧伤高凝状态(热毒血瘀型)者,患者采用常规治疗;中药治疗组为大面积烧伤高凝状态(热毒血瘀型)者,患者入院后在采用常规治疗的基础上每日服用血府逐瘀汤一剂.常规治疗组及中药治疗组于伤后第3、6天取血测定活化部分凝血活酶时间(APTT)、抗凝血酶Ⅲ抗原(AT-Ⅲ:Ag,)、蛋白C活性(PC:a,);血浆B-血小板球蛋白(β-TG)和血小板第四因子(PF4)、纤维蛋白肽(FPA)、组织纤溶酶原激活物活性(t-PA:a).结果常规治疗组及中药治疗组与对照组相比均存在高凝状态,而中药治疗组与常规治疗组相比凝血系统功能下降,抗凝系统功能和水平改善,血小板系统活化及释放功能明显下降,纤溶能力增强.结论清热凉血法对大面积烧伤高凝状态(热毒血瘀型)的临床治疗有积极作用.
목적 탐토응용청열량혈법대대면적소상조기고응상태(열독혈어형)적림상치료작용.방법 본연구분위대조조, 상규치료조급중약치료조.대조조위정상건강헌혈자;상규치료조위대면적소상고응상태(열독혈어형)자,환자채용상규치료;중약치료조위대면적소상고응상태(열독혈어형)자,환자입원후재채용상규치료적기출상매일복용혈부축어탕일제.상규치료조급중약치료조우상후제3、6천취혈측정활화부분응혈활매시간(APTT)、항응혈매Ⅲ항원(AT-Ⅲ:Ag,)、단백C활성(PC:a,);혈장B-혈소판구단백(β-TG)화혈소판제사인자(PF4)、섬유단백태(FPA)、조직섬용매원격활물활성(t-PA:a).결과 상규치료조급중약치료조여대조조상비균존재고응상태,이중약치료조여상규치료조상비응혈계통공능하강,항응계통공능화수평개선,혈소판계통활화급석방공능명현하강,섬용능력증강.결론 청열량혈법대대면적소상고응상태(열독혈어형)적림상치료유적겁작용.
Objective To study the treatment effects of the Qingrejliangxue method with hypercoagulability on massive burn patients. Methods Control group were the healthy persons, routine treatment group were massive burn patients with hypercoagulability of by routine treatment, Chinese medicinal group were massive burn patients with hypercoagulability by Xuefuzhuyu decoction. Chinese medicine was taken orally in Chinese medicinal group, once a day. On the third and sixth day, prothrombin activated partial thromboplastin time(APTT),fibrinopeptide A (FPA) ,antithrombin-III antigen (AT-III:Ag) , protein C activated (PC: a),tissue plasminogen activator activated(t-PA:a),blood plasma β-thrombocy to globulin(β-TG),platelet fourth factor(PF4) were measured.Results In chinese medicinal group, the function of coagulative system decreased, the function and level of anticoagulative system improved, the activation and releasion of blood platelet decreased obviously, the competence of fibrinolysis enhanced. Conclusions The Chinese medicine(Qingrejliangxue method) has active effects on hypercoagulability of massive burn patients.