CAJ | 학술논문

目的：观察骨桥蛋白（osteopontin，OPN）及细胞粘附分子CD44v6在牙源性角化囊性瘤（keratocystic odontogenic tumor ， KCOT）中开窗减压前后表达水平的变化。方法：收集16例经病理证实的KCOT患者开窗减压前后的病理标本，应用免疫组织化学染色法检测OPN及CD44v6的表达，并进行统计分析。结果：开窗减压前，OPN及CD44v6在KCOT中均呈高表达。减压后，16例患者OPN均呈阴性表达，统计学分析其表达在开窗后显著下降（P＜0．05）；CD44v6在开窗减压后标本中，10例（63％）表达下降，5例（31％）表达未发生变化，1例（6％）表达升高，统计学分析其表达在开窗后显著下降（P＜0．05）。结论：OPN及CD44v6在KCOT中呈高表达，开窗减压后二者的表达水平明显降低，这可能是开窗减压术治疗KCOT的部分机制。
목적：관찰골교단백（osteopontin，OPN）급세포점부분자CD44v6재아원성각화낭성류（keratocystic odontogenic tumor ， KCOT）중개창감압전후표체수평적변화。방법：수집16례경병리증실적KCOT환자개창감압전후적병리표본，응용면역조직화학염색법검측OPN급CD44v6적표체，병진행통계분석。결과：개창감압전，OPN급CD44v6재KCOT중균정고표체。감압후，16례환자OPN균정음성표체，통계학분석기표체재개창후현저하강（P＜0．05）；CD44v6재개창감압후표본중，10례（63％）표체하강，5례（31％）표체미발생변화，1례（6％）표체승고，통계학분석기표체재개창후현저하강（P＜0．05）。결론：OPN급CD44v6재KCOT중정고표체，개창감압후이자적표체수평명현강저，저가능시개창감압술치료KCOT적부분궤제。
Objective:To investigate the expression of osteopontin (OPN) and CD44v6 and their significance in keratocystic odonto-genic tumor ( KCOT) before and after decompression .Methods:All 16 pairs of paraffin-embedded tissue specimens of KCOT before and after decompression were collected and then used for immunohistochemical detection of OPN and CD 44v6.The results were statistically analyzed.Results:The expression of OPN in KCOT was down-regulated after decompression (P<0.05).And CD44v6 expression in post-operative KCOT epithelium was significantly less than that in preoperative KCOT epithelium (P<0.05).Conclusions:The local aggres-sive behavior of KCOT epithelium after decompression was decreased , which may be part of the mechanisms of decompression therapy .