中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2012年
12期
1056-1059
,共4页
位慧芳%麻琳%单培彦%江文静
位慧芳%痳琳%單培彥%江文靜
위혜방%마림%단배언%강문정
痴呆,血管性%血管紧张素原%多态性,单核苷酸%血压
癡呆,血管性%血管緊張素原%多態性,單覈苷痠%血壓
치태,혈관성%혈관긴장소원%다태성,단핵감산%혈압
Dementia,vascular%Angiotensinogen%Polymophism,single neucleotide%Blood pressure variability%Blood pressure
目的 探索血压波动及血管紧张素原(AGT) M235T基因多态性与皮层下动脉硬化性脑病(BD)的关系.方法 BD患者122例(BD组),原发性高血压病(EH)患者108例(EH组),分别对所有入组者进行24 h动态血压监测,并采用聚合酶链式反应-限制性片段长度多态性(PCR-PFLP)技术检测其AGT M235T基因多态性.结果 MM+MT基因型及M等位基因的分布频率在BD组(51.6％,29.9％)明显高于EH组(27.8％,16.2％)(x2＝13.543,11.995,P＜0.01);BD组患者夜间收缩压波动(11.8±2.8)mm Hg、舒张压波动(9.1±2.5)mm Hg及24 h舒张压波动(11.6±6.0)mm Hg水平高于EH组患者的对应水平(10.9±2.4,8.2±3.2,10.1±4.6)mm Hg(t＝2.59、2.64、2.09,均P＜0.05).反杓型血压昼夜节律在BD组分布频率(32.8％)明显高于EH(16.7％)组(x2 ＝7.894,P＜0.01).同时BD患者中,MM+ MT基因型者中反杓型血压昼夜节律的分布频率(44.4％)高于TT基因型者(20.3％)(x2 ＝8.760,P＜0.01).结论 BD患者夜间舒张压、收缩压及24 h舒张压波动明显且其AGT M235T基因多态性更多地表现为MM+MT型,而MM+ MT基因型的BD患者反杓型血压昼夜节律的分布频率更高.
目的 探索血壓波動及血管緊張素原(AGT) M235T基因多態性與皮層下動脈硬化性腦病(BD)的關繫.方法 BD患者122例(BD組),原髮性高血壓病(EH)患者108例(EH組),分彆對所有入組者進行24 h動態血壓鑑測,併採用聚閤酶鏈式反應-限製性片段長度多態性(PCR-PFLP)技術檢測其AGT M235T基因多態性.結果 MM+MT基因型及M等位基因的分佈頻率在BD組(51.6％,29.9％)明顯高于EH組(27.8％,16.2％)(x2＝13.543,11.995,P＜0.01);BD組患者夜間收縮壓波動(11.8±2.8)mm Hg、舒張壓波動(9.1±2.5)mm Hg及24 h舒張壓波動(11.6±6.0)mm Hg水平高于EH組患者的對應水平(10.9±2.4,8.2±3.2,10.1±4.6)mm Hg(t＝2.59、2.64、2.09,均P＜0.05).反杓型血壓晝夜節律在BD組分佈頻率(32.8％)明顯高于EH(16.7％)組(x2 ＝7.894,P＜0.01).同時BD患者中,MM+ MT基因型者中反杓型血壓晝夜節律的分佈頻率(44.4％)高于TT基因型者(20.3％)(x2 ＝8.760,P＜0.01).結論 BD患者夜間舒張壓、收縮壓及24 h舒張壓波動明顯且其AGT M235T基因多態性更多地錶現為MM+MT型,而MM+ MT基因型的BD患者反杓型血壓晝夜節律的分佈頻率更高.
목적 탐색혈압파동급혈관긴장소원(AGT) M235T기인다태성여피층하동맥경화성뇌병(BD)적관계.방법 BD환자122례(BD조),원발성고혈압병(EH)환자108례(EH조),분별대소유입조자진행24 h동태혈압감측,병채용취합매련식반응-한제성편단장도다태성(PCR-PFLP)기술검측기AGT M235T기인다태성.결과 MM+MT기인형급M등위기인적분포빈솔재BD조(51.6％,29.9％)명현고우EH조(27.8％,16.2％)(x2＝13.543,11.995,P＜0.01);BD조환자야간수축압파동(11.8±2.8)mm Hg、서장압파동(9.1±2.5)mm Hg급24 h서장압파동(11.6±6.0)mm Hg수평고우EH조환자적대응수평(10.9±2.4,8.2±3.2,10.1±4.6)mm Hg(t＝2.59、2.64、2.09,균P＜0.05).반표형혈압주야절률재BD조분포빈솔(32.8％)명현고우EH(16.7％)조(x2 ＝7.894,P＜0.01).동시BD환자중,MM+ MT기인형자중반표형혈압주야절률적분포빈솔(44.4％)고우TT기인형자(20.3％)(x2 ＝8.760,P＜0.01).결론 BD환자야간서장압、수축압급24 h서장압파동명현차기AGT M235T기인다태성경다지표현위MM+MT형,이MM+ MT기인형적BD환자반표형혈압주야절률적분포빈솔경고.
Objective To detect the relationship of blood pressure variability (BPV) and angiotensinogen(AGT) T235M polymorphism with Binswanger's disease (BD).Methods Totally 122 cases with BD and 108 cases with essential hypertension had been enrolled.Ambulatory blood pressure monitoring was used to get the data of BPV and mean blood pressure (MBP).PCR-RFLP was applied to detect genotype of AGT T235M.Results Distribution of MM+MT genotype and frequency of M allelic were higher in BD group (51.6％,29.9％) than in hypertension group(27.8％,16.2％)(x2 ＝13.543,11.995,P＜0.01).The variability of night time blood pressure (11.8±2.8,9.1±2.5) and 24 hours diastolic blood pressure(11.6±6.0) in BD group were increased compared with those in hypertension groups(10.9±2.4,8.2±3.2,10.1±4.6)(t＝2.59,2.64,2.09,all P＜0.05).Prevalence of anti-dipper was higher in BD group (32.8％) than in EH group (16.7％)(x2 ＝7.894,P＜0.01).Among BD patients,anti-dipper who carried MM or MT genotypes (44.4 ％) was more than that who carried TT genotype (20.3％) (x2 ＝ 8.760,P＜ 0.01).Conclusions Fluctuations of nighttime blood pressure and diastolic pressure are higher in patients with BD,and the relative frequency of MM or MT genotype is higher.Moreover,among patients with BD who carried MM or MT genotypes are apt to have anti-dipper.MM or MT genotype is related to BD by means of affecting blood pressure circadian rhythms probably.
