CAJ | 학술논문

目的本研究拟通过观察乌司他丁(ulinastatin,UT)对乳腺癌患者围术期凝血功能的影响,了解乌司他丁的血液保护机制.方法选择行乳腺癌改良根治术的患者40例,分为乌司他丁组(U组,n=20)和对照组(C组,n=20例),U组于麻醉后切皮前静脉输入乌司他丁4000 U/kg,C组给予相同容量的生理盐水,所有患者分别于给药前(T0)和给药后1 h(T1)抽取外周静脉血1 ml,用Sonoclot凝血及血小板功能分析仪测定凝血激活时间(SonACT)、凝血速率(CR)、血小板功能(PF).结果与C组比较,U组SonACT、PF在T1时增高,差异有统计学意义(P＜0.05)；与T0比较,U组SonACT在T1时延长(P＜0.05),PF在T1时增加(P＜0.01),差异有统计学意义.结论乌司他丁能改善围术期的凝血功能及血小板功能,可能对减少术中微血栓综合征,预防术后深静脉血栓形成有一定的临床意义.
목적 본연구의통과관찰오사타정(ulinastatin,UT)대유선암환자위술기응혈공능적영향,료해오사타정적혈액보호궤제.방법 선택행유선암개량근치술적환자40례,분위오사타정조(U조,n=20)화대조조(C조,n=20례),U조우마취후절피전정맥수입오사타정4000 U/kg,C조급여상동용량적생리염수,소유환자분별우급약전(T0)화급약후1 h(T1)추취외주정맥혈1 ml,용Sonoclot응혈급혈소판공능분석의측정응혈격활시간(SonACT)、응혈속솔(CR)、혈소판공능(PF).결과 여C조비교,U조SonACT、PF재T1시증고,차이유통계학의의(P＜0.05)；여T0비교,U조SonACT재T1시연장(P＜0.05),PF재T1시증가(P＜0.01),차이유통계학의의.결론 오사타정능개선위술기적응혈공능급혈소판공능,가능대감소술중미혈전종합정,예방술후심정맥혈전형성유일정적림상의의.
Objective This trial was to observe the effect of Ulinastatin on coagulation functions in patients during operation period,and to investigate the protective mechanisms of Ulinastatin.Methods Forty patients were randomly divided into Ulinastatin group (Group U,n =20) and control group (Group C,n =20).Group U was infused intravenously ulinastatin 4000 U/kg (diluted with saline to 30 ml,20min losers) after anesthesia and before cutting skin,while Group C received the same volume of normal saline.All patients were phlebotomized 1 ml peripheral blood before administered (T0) and after 1 hour (T1),respectively.Coagulation activation time (SonACT),clot rate (CR) and platelet function (PF)were detected by sonoclot coagulation analyzer and platelet function analyzer.Results Compared with group C (controlled group),SonACT of Group U was prolonged significantly at T1 (P ＜ 0.05),and PF were increased at T1 (P ＜ 0.05) ; Compared with T0,SonACT and PF were increased at T1,respectively (P ＜ 0.01).Conclusions Ulinastatin can improve perioperative coagulation function and platelet function.It may reduce intraoperative micro-thrombosis syndrome and postoperative deep vein thrombosis.