中华诊断学电子杂志
中華診斷學電子雜誌
중화진단학전자잡지
2014年
1期
58-60
,共3页
徐存理%刘洪强%庆贤%王瑞科
徐存理%劉洪彊%慶賢%王瑞科
서존리%류홍강%경현%왕서과
镇痛药%头痛症%继发性%认知%事件相关电位,P300
鎮痛藥%頭痛癥%繼髮性%認知%事件相關電位,P300
진통약%두통증%계발성%인지%사건상관전위,P300
Analgesils%Headache disorders,secondary%Cognition%Event-related potentials,P300
目的:探讨药物滥用性头痛(MOH )患者认知功能及认知电位的变化情况。方法MOH患者(观察组)及对照组各30例,两组均进行P300、简易精神状态量表(MMSE )检测。采用SPSS 10.0软件进行数据处理,P300潜伏期、波幅比较采用t检验。结果两组P300靶刺激中P3潜伏期、波幅比较均差异有统计学意义:观察组 P3潜伏期[分别为(393.70±42.60)ms]较对照组[(331.05±22.35)ms]延长,差异有统计学意义(t =7.13,P <0.05);观察组 P3波幅[(3.40±2.30)uV]较对照组[(6.20±2.40)uV ]明显降低,差异也有统计学意义(t =4.59,P<0.05)。两组MMSE评分比较,观察组总分、定向力、记忆力、计算力、回忆力、语言能力[(24.00±2.21)分,(8.15±0.86)分,(2.88±0.23)分,(3.07±1.04)分,(1.72±0.89)分,(8.42±1.33)分]低于对照组[分别为(27.07±2.06)分,(9.28±1.03)分,(3.01±0.26)分,(3.25±1.20)分,(1.92±0.90)分,(9.69±1.44)分],总分、定向力、语言能力评分差异有统计学意义(t =3.66,3.19,3.34;P<0.05)。结论 MOH患者存在轻度的认知功能障碍,认知电位P300为MOH患者认知功能障碍的诊断提供一客观指标。
目的:探討藥物濫用性頭痛(MOH )患者認知功能及認知電位的變化情況。方法MOH患者(觀察組)及對照組各30例,兩組均進行P300、簡易精神狀態量錶(MMSE )檢測。採用SPSS 10.0軟件進行數據處理,P300潛伏期、波幅比較採用t檢驗。結果兩組P300靶刺激中P3潛伏期、波幅比較均差異有統計學意義:觀察組 P3潛伏期[分彆為(393.70±42.60)ms]較對照組[(331.05±22.35)ms]延長,差異有統計學意義(t =7.13,P <0.05);觀察組 P3波幅[(3.40±2.30)uV]較對照組[(6.20±2.40)uV ]明顯降低,差異也有統計學意義(t =4.59,P<0.05)。兩組MMSE評分比較,觀察組總分、定嚮力、記憶力、計算力、迴憶力、語言能力[(24.00±2.21)分,(8.15±0.86)分,(2.88±0.23)分,(3.07±1.04)分,(1.72±0.89)分,(8.42±1.33)分]低于對照組[分彆為(27.07±2.06)分,(9.28±1.03)分,(3.01±0.26)分,(3.25±1.20)分,(1.92±0.90)分,(9.69±1.44)分],總分、定嚮力、語言能力評分差異有統計學意義(t =3.66,3.19,3.34;P<0.05)。結論 MOH患者存在輕度的認知功能障礙,認知電位P300為MOH患者認知功能障礙的診斷提供一客觀指標。
목적:탐토약물람용성두통(MOH )환자인지공능급인지전위적변화정황。방법MOH환자(관찰조)급대조조각30례,량조균진행P300、간역정신상태량표(MMSE )검측。채용SPSS 10.0연건진행수거처리,P300잠복기、파폭비교채용t검험。결과량조P300파자격중P3잠복기、파폭비교균차이유통계학의의:관찰조 P3잠복기[분별위(393.70±42.60)ms]교대조조[(331.05±22.35)ms]연장,차이유통계학의의(t =7.13,P <0.05);관찰조 P3파폭[(3.40±2.30)uV]교대조조[(6.20±2.40)uV ]명현강저,차이야유통계학의의(t =4.59,P<0.05)。량조MMSE평분비교,관찰조총분、정향력、기억력、계산력、회억력、어언능력[(24.00±2.21)분,(8.15±0.86)분,(2.88±0.23)분,(3.07±1.04)분,(1.72±0.89)분,(8.42±1.33)분]저우대조조[분별위(27.07±2.06)분,(9.28±1.03)분,(3.01±0.26)분,(3.25±1.20)분,(1.92±0.90)분,(9.69±1.44)분],총분、정향력、어언능력평분차이유통계학의의(t =3.66,3.19,3.34;P<0.05)。결론 MOH환자존재경도적인지공능장애,인지전위P300위MOH환자인지공능장애적진단제공일객관지표。
Objectives To explore the changes of cognitive function and potential in patients with medication-overuse headache (MOH).Methods The subjects were divided into two groups:observation group (patients with MOH,n=30 )and control group (n=30 ).P300 was used to detect the cognitive potential and mini mental state examination (MMSE)was performed to evaluate the cognitive function of the subjects.Results The differences between the two groups were significant.The P3 latency in observation group [(393.70 ±42.60)ms]was more prolonged than that in the control group (331.05 ±22.35)ms]. The difference between the two groups was significant(t =7.13,P <0.05);The amplitudes of P3 in observation group [(3.40 ±2.30)uV],was lower than that in the control group [(6.20 ±2.40)uV].The difference between the two groups was also significant(t =4.59,P <0.05 ).The MMSE in observation group were shown as follows:total score (24.00 ±2.21),orientation (8.15 ±0.86),anamnesis (2.88 ± 0.23),calculation (3.07 ±1.04),recall (1.72 ±0.89)and language (8.42 ±1.33).In control group, the MMSE were shown as total score (27.07 ±2.06),orientation (9.28 ±1.03),anamnesis (3.01 ± 0.26),calculation (3.25 ±1.20),recall (1.92 ±0.90)and language (9.69 ±1.44).The differences between the two groups were all significant (t=3.66 ,3.19,3.34,P<0.01 ).Conclusion The patients with MOH had the mild cognitive impairment,and P300 cognitive potential could provide objective indicators for the diagnosis of cognitive dysfunction of patients with MOH.