中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
5期
950-955
,共6页
微RNAs%上皮间质转化现象%肿瘤转移
微RNAs%上皮間質轉化現象%腫瘤轉移
미RNAs%상피간질전화현상%종류전이
MicroRNAs%Epithelial-mesenchymal transition%Neoplasm metastasis
microRNAs是一类单链、小分子非编码RNAs，通过调控基因表达，对于生命活动的各个过程起着重要的调控作用。通过作用于相关的mRNA分子，microRNAs调控肿瘤的发生和发展。microRNAs对于基因表达表达的发挥重要的调控作用，到底对肿瘤的发生具有促进作用还是抑制作用一直存在争议。到目前为止，作为肿瘤标记物和治疗的靶向分子还存在很大的限制性。文中涉及microRNAs的正负功能态调节作用，从理论上阐明其在肿瘤转移中的作用，并对microRNA的临床应用及抗癌前景提出了展望。
microRNAs是一類單鏈、小分子非編碼RNAs，通過調控基因錶達，對于生命活動的各箇過程起著重要的調控作用。通過作用于相關的mRNA分子，microRNAs調控腫瘤的髮生和髮展。microRNAs對于基因錶達錶達的髮揮重要的調控作用，到底對腫瘤的髮生具有促進作用還是抑製作用一直存在爭議。到目前為止，作為腫瘤標記物和治療的靶嚮分子還存在很大的限製性。文中涉及microRNAs的正負功能態調節作用，從理論上闡明其在腫瘤轉移中的作用，併對microRNA的臨床應用及抗癌前景提齣瞭展望。
microRNAs시일류단련、소분자비편마RNAs，통과조공기인표체，대우생명활동적각개과정기착중요적조공작용。통과작용우상관적mRNA분자，microRNAs조공종류적발생화발전。microRNAs대우기인표체표체적발휘중요적조공작용，도저대종류적발생구유촉진작용환시억제작용일직존재쟁의。도목전위지，작위종류표기물화치료적파향분자환존재흔대적한제성。문중섭급microRNAs적정부공능태조절작용，종이론상천명기재종류전이중적작용，병대microRNA적림상응용급항암전경제출료전망。
MicroRNAs are single-stranded RNA molecules that control gene expression in many cellular processes. These molecules typically reduce the translation and stability of mRNAs, including those genes that mediate processes in tumorigenesis. MicroRNAs have been established as key regulators of gene-expression, and their putative roles as oncogenes and tumour suppressor genes has provided a potentially new dimension to our clinical approach to cancer diagnosis and treatment. Their role as biomarkers and therapeutic targets is appealing but several obstacles have as yet limited our ability to translate this potential into a clinical reality. This review focuses on currently accepted roles of microRNAs in cancer pathogenesis, and highlights the challenges and breakthroughs in this field to date with relevance to the cancer clinic.
