中华骨质疏松和骨矿盐疾病杂志
中華骨質疏鬆和骨礦鹽疾病雜誌
중화골질소송화골광염질병잡지
CHINESE JOURNAL OF OSTEOPOROSIS AND BONE MINERAL RESEARCH
2014年
1期
20-24
,共5页
万勇%郎红梅%艾智华%游志清%郭蔚%程莹%付静%廖霞%张学翠%金小岚
萬勇%郎紅梅%艾智華%遊誌清%郭蔚%程瑩%付靜%廖霞%張學翠%金小嵐
만용%랑홍매%애지화%유지청%곽위%정형%부정%료하%장학취%금소람
绝经后骨质疏松%25羟维生素D%维生素D缺乏
絕經後骨質疏鬆%25羥維生素D%維生素D缺乏
절경후골질소송%25간유생소D%유생소D결핍
postmenopausal osteoporosis%25 hydroxyvitamin D%vitamin D deficiency
目的：了解成都地区部分绝经后妇女维生素 D水平，观察血清25（ OH） D3与骨密度、年龄、绝经年龄、体重指数的关系。方法用整群随机抽样方法抽取成都地区291名绝经后女性，平均年龄（63.9±9.7）岁，按每10岁为1个年龄组分组。记录身高、体重、绝经年龄等基本信息，使用双能X线吸收骨密度仪（DXA）测量腰椎2-4椎体（L2-4）、左髋关节股骨颈和全髋骨密度（BMD），用酶联免疫法测定血清25（OH）D3水平。分析绝经后女性骨量及血清25（ OH） D3分布情况。结果超过半数的受试者（52.2％）患骨质疏松症，发病率随年龄增加而增高，＞80岁老年女性发病率达76.47％。血清25（OH）D3水平平均为18.37 ng/mL，维生素D缺乏发生率为68.38％。血清25（ OH） D3水平与骨密度、年龄、绝经年龄无关，与BMI 呈负相关（ P＝0.000）。结论成都地区部分绝经后妇女普遍存在维生素 D缺乏，绝经后妇女应及时补充维生素D。
目的：瞭解成都地區部分絕經後婦女維生素 D水平，觀察血清25（ OH） D3與骨密度、年齡、絕經年齡、體重指數的關繫。方法用整群隨機抽樣方法抽取成都地區291名絕經後女性，平均年齡（63.9±9.7）歲，按每10歲為1箇年齡組分組。記錄身高、體重、絕經年齡等基本信息，使用雙能X線吸收骨密度儀（DXA）測量腰椎2-4椎體（L2-4）、左髖關節股骨頸和全髖骨密度（BMD），用酶聯免疫法測定血清25（OH）D3水平。分析絕經後女性骨量及血清25（ OH） D3分佈情況。結果超過半數的受試者（52.2％）患骨質疏鬆癥，髮病率隨年齡增加而增高，＞80歲老年女性髮病率達76.47％。血清25（OH）D3水平平均為18.37 ng/mL，維生素D缺乏髮生率為68.38％。血清25（ OH） D3水平與骨密度、年齡、絕經年齡無關，與BMI 呈負相關（ P＝0.000）。結論成都地區部分絕經後婦女普遍存在維生素 D缺乏，絕經後婦女應及時補充維生素D。
목적：료해성도지구부분절경후부녀유생소 D수평，관찰혈청25（ OH） D3여골밀도、년령、절경년령、체중지수적관계。방법용정군수궤추양방법추취성도지구291명절경후녀성，평균년령（63.9±9.7）세，안매10세위1개년령조분조。기록신고、체중、절경년령등기본신식，사용쌍능X선흡수골밀도의（DXA）측량요추2-4추체（L2-4）、좌관관절고골경화전관골밀도（BMD），용매련면역법측정혈청25（OH）D3수평。분석절경후녀성골량급혈청25（ OH） D3분포정황。결과초과반수적수시자（52.2％）환골질소송증，발병솔수년령증가이증고，＞80세노년녀성발병솔체76.47％。혈청25（OH）D3수평평균위18.37 ng/mL，유생소D결핍발생솔위68.38％。혈청25（ OH） D3수평여골밀도、년령、절경년령무관，여BMI 정부상관（ P＝0.000）。결론성도지구부분절경후부녀보편존재유생소 D결핍，절경후부녀응급시보충유생소D。
Objective To determine the level of serum vitamin D in postmenopausal women in Chengdu , and to explore the corelation with bone mineral density , age, menopausal age and body mass index (BMI).Methods Using cluster random sampling method , 291 postmenopausal women were recruited and their mean age is 63.9 ±9.7 years. Height, weight, age, menopausal age and general information were recorded at the same time .Their BMD at lumbar 2-4 (L2-L4), left femoral neck, total hip were measured by dual-energy X-ray absorptiometry (DXA).Simultaneously, the serum level of 25(OH)D3 was measured by enzyme-linked immunosorbent assay.To analyze the distribution of bone mass and serum 25(OH)D3 in postmenopausal women, they were divided into five groups according to age .Results More than half (52.2%) postmenopausal women suffered from osteoporosis .Morbidity rate of osteoporosis increased gradually with the age increasing , morbidity rate of elderly women over the age of 80 is the highest , which is 76.47%.The mean values of serum 25(OH)D3 was 18.37 ng/mL in 291 postmenopausal women.The prevalence of vitamin D deficiency is 68.38%in postmenopausal women .No linear correlation relationships was found between serum 25( OH) D3 and femoral neck BMD, total hip BMD, L2-L4 lumbar spine BMD.Serum 25(OH)D3 level was negatively correlated with BMI (P=0.000 ) .Conclusion Osteoporosis and vitamin D deficiency is very prevalent in postmenopausal women living in Cheng -du.To prevent osteoporotic frature , vitamin D supplementation should be recommended in postmenopausal women .
