CAJ | 학술논문

目的：探讨针对初发2型糖尿病的两种联合治疗策略的临床疗效，寻找更佳的治疗方式。方法选取重庆市石柱土家族自治县人民医院收治的120例初发2型糖尿病患者，分为男女两组（n=60）。再将男女各组分成行A方案和行B方案治疗的两组（n=30）。观察各组治疗前后空腹血糖(FPG)、餐后2 h血糖(2 hPG)、糖化血红蛋白(HbA1 c)、空腹胰岛素(FINS)、胰岛素分泌指数(HOMA-IS)、胰岛素抵抗指数(HOMA-IR)、空腹C肽(FCP)及餐后2 hC肽(2 hPCP)。结果所有患者治疗后临床指标和胰岛B细胞功能都较治疗前有显著改善，差异有统计学意义（P＜0.05）；对于男性患者，行A方案显著优于B方案，差异有统计学意义（P＜0.05）；对于女性患者，行B方案显著优于行A方案，差异有统计学意义（P＜0.05）。结论对于初发2型糖尿病的患者，可根据其性别的不同，行不同的治疗方案，可达到最佳的治疗效果。
목적：탐토침대초발2형당뇨병적량충연합치료책략적림상료효，심조경가적치료방식。방법선취중경시석주토가족자치현인민의원수치적120례초발2형당뇨병환자，분위남녀량조（n=60）。재장남녀각조분성행A방안화행B방안치료적량조（n=30）。관찰각조치료전후공복혈당(FPG)、찬후2 h혈당(2 hPG)、당화혈홍단백(HbA1 c)、공복이도소(FINS)、이도소분비지수(HOMA-IS)、이도소저항지수(HOMA-IR)、공복C태(FCP)급찬후2 hC태(2 hPCP)。결과소유환자치료후림상지표화이도B세포공능도교치료전유현저개선，차이유통계학의의（P＜0.05）；대우남성환자，행A방안현저우우B방안，차이유통계학의의（P＜0.05）；대우녀성환자，행B방안현저우우행A방안，차이유통계학의의（P＜0.05）。결론대우초발2형당뇨병적환자，가근거기성별적불동，행불동적치료방안，가체도최가적치료효과。
Objective Investigating the newly diagnosed type 2 diabetes for clinical efficacy of two combination therapy strategies, finding better clinical treatment.Method Selecting 120 cases of newly diagnosed type 2 diabetic patients were divided into two groups of 60 men and women in our hospital, then men and women were divided into two groups of 30 people with A and B treatment program;observing fasting plasma glucose (FPG),2 h postprandial blood glucose (2 hPG),glycosylated hemoglobin (HbA1 c),fasting insulin (FINS),insulin secretion index (HOMA-IS),insulin resistance index (HOMA-IR),fasting C-peptide (FCP) and postprandial peptide 2 hC (2 hPCP) in each group before and after treatment. Results The clinical indicators and islet B cell function as compared with before treatment were significantly improved (P<0.05);For male patients, plan A program was significantly better than plan B (P<0.05);For female patients, plan B program significantly better than plan A (P<0.05). Conclusion For newly diagnosed type 2 diabetes, according to their different gender, different treatment options line can achieve different therapeutic effect.