徐州医学院学报
徐州醫學院學報
서주의학원학보
ACTA ACADEMIAE MEDICINAE XUZHOU
2013年
11期
792-794
,共3页
MACC1%HGF/c-Met信号通路%EMT%肿瘤浸润%肿瘤转移
MACC1%HGF/c-Met信號通路%EMT%腫瘤浸潤%腫瘤轉移
MACC1%HGF/c-Met신호통로%EMT%종류침윤%종류전이
结肠癌转移相关基因1(metastasis-associated in colon cancer-1,MACC1)是一个在多种恶性肿瘤中调控肿瘤生长和转移的重要基因.MACC1通过调控肝细胞生长因子(hepatocyte growth factor,HGF)/间质向上皮转化因子(mesenchymal-epithelial transition factor,c-Met)信号通路诱导上皮向间质转化(epithelial-mesenchymal transition,EMT),促进肿瘤细胞的迁移、浸润和转移.因此,本文将MACC1、HGF/c-Met和EMT三者结合在一起,探索三者与肿瘤侵袭转移的相关性.
結腸癌轉移相關基因1(metastasis-associated in colon cancer-1,MACC1)是一箇在多種噁性腫瘤中調控腫瘤生長和轉移的重要基因.MACC1通過調控肝細胞生長因子(hepatocyte growth factor,HGF)/間質嚮上皮轉化因子(mesenchymal-epithelial transition factor,c-Met)信號通路誘導上皮嚮間質轉化(epithelial-mesenchymal transition,EMT),促進腫瘤細胞的遷移、浸潤和轉移.因此,本文將MACC1、HGF/c-Met和EMT三者結閤在一起,探索三者與腫瘤侵襲轉移的相關性.
결장암전이상관기인1(metastasis-associated in colon cancer-1,MACC1)시일개재다충악성종류중조공종류생장화전이적중요기인.MACC1통과조공간세포생장인자(hepatocyte growth factor,HGF)/간질향상피전화인자(mesenchymal-epithelial transition factor,c-Met)신호통로유도상피향간질전화(epithelial-mesenchymal transition,EMT),촉진종류세포적천이、침윤화전이.인차,본문장MACC1、HGF/c-Met화EMT삼자결합재일기,탐색삼자여종류침습전이적상관성.
