上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
7期
58-59,62
,共3页
地氯雷他定%口崩片%崩解时限
地氯雷他定%口崩片%崩解時限
지록뢰타정%구붕편%붕해시한
desloratadine%orally disintegrating tablets%direct compression
目的：筛选地氯雷他定口崩片的最佳处方和工艺流程，并进行质量研究。方法：考察不同种类、不同剂量的填充剂和矫味剂对地氯雷他定口崩片口感及崩解时限的影响，并制定合理的质量标准。结果：按照筛选出的最佳处方制备的地氯雷他定口崩片口感易于患者接受，平均崩解时限在30 s之内，且适合工业生产。结论：本法处方合理、工艺简单，生产的片剂可用于临床。
目的：篩選地氯雷他定口崩片的最佳處方和工藝流程，併進行質量研究。方法：攷察不同種類、不同劑量的填充劑和矯味劑對地氯雷他定口崩片口感及崩解時限的影響，併製定閤理的質量標準。結果：按照篩選齣的最佳處方製備的地氯雷他定口崩片口感易于患者接受，平均崩解時限在30 s之內，且適閤工業生產。結論：本法處方閤理、工藝簡單，生產的片劑可用于臨床。
목적：사선지록뢰타정구붕편적최가처방화공예류정，병진행질량연구。방법：고찰불동충류、불동제량적전충제화교미제대지록뢰타정구붕편구감급붕해시한적영향，병제정합리적질량표준。결과：안조사선출적최가처방제비적지록뢰타정구붕편구감역우환자접수，평균붕해시한재30 s지내，차괄합공업생산。결론：본법처방합리、공예간단，생산적편제가용우림상。
Objective:To optimize the formulation and process for the orally disintegrating tablets of desloratadine and assess its quality. Methods:The effects of the different types and doses of fillers and flavoring agents on the taste and disintegration of the tablets were studied and a reasonable quality standard was developed. Results:The tablets prepared by optimum formulation were well-tasted, the time for their disintegration was within 30 seconds and the formulation was suitable for the industrial production. Conclusion:The formulation is reasonable and the process is simple. The prepared tablets are suitable for clinical use.
