CAJ | 학술논문

目的：探讨抗抑郁治疗对于脑卒中后抑郁和神经功能康复的影响。方法选取我院收治的48例脑卒中患者，随机均分为对照组和观察组，对照组给予常规治疗，观察组在常规治疗的基础上加用抗抑郁类药物帕罗西汀片治疗，均治疗12周。采用汉密尔顿抑郁量表（HAMD）评分评价抑郁症状，临床神经功能缺损程度（NIHSS）评分评价神经功能，Barthel指数评价日常生活活动能力（ADL ）。比较2组患者治疗前后HAMD、NIHSS和ADL评分，抑郁改善有效率和神经功能恢复有效率的差异。结果2组患者治疗后HAMD、NIHSS和ADL评分均较治疗前改善，观察组改善优于对照组（P＜0.05）；观察组抑郁改善有效率和神经功能恢复有效率均显著优于对照组（ P＜0.05）。结论在治疗脑卒中的同时使用抗抑郁药物治疗效果确切，能显著改善抑郁症状，有利于神经功能的康复，明显提高生活质量，减少致残率。
목적：탐토항억욱치료대우뇌졸중후억욱화신경공능강복적영향。방법선취아원수치적48례뇌졸중환자，수궤균분위대조조화관찰조，대조조급여상규치료，관찰조재상규치료적기출상가용항억욱류약물파라서정편치료，균치료12주。채용한밀이돈억욱량표（HAMD）평분평개억욱증상，림상신경공능결손정도（NIHSS）평분평개신경공능，Barthel지수평개일상생활활동능력（ADL ）。비교2조환자치료전후HAMD、NIHSS화ADL평분，억욱개선유효솔화신경공능회복유효솔적차이。결과2조환자치료후HAMD、NIHSS화ADL평분균교치료전개선，관찰조개선우우대조조（P＜0.05）；관찰조억욱개선유효솔화신경공능회복유효솔균현저우우대조조（ P＜0.05）。결론재치료뇌졸중적동시사용항억욱약물치료효과학절，능현저개선억욱증상，유리우신경공능적강복，명현제고생활질량，감소치잔솔。
Objective To investigate the clinical efficacy of antidepressant therapy on depression and neurological rehabili-tation of stroke patients.Methods 48 stroke patients in our hospital were randomly divided into control group and observation group. Control group received conventional treatment. Observation group received antidepressant therapy based on convention-al treatment. All patients were treated for 12 weeks. Hamilton Depression Scale (HAMD) score was used to evaluate depres-sive symptoms. Clinical neurological deficits (NIHSS) score was used to evaluate neurological function. Barthel Index was used to evaluate activities of daily living (ADL). The HAMD ,NIHSS and ADL scores before and after treatment ,the efficiency of depression improvement and nerve function recovery efficiency of two groups were compared. Results HAMD ,NIHSS and ADL scores of two groups after treatment were improved than those before treatment ,those of observation group were signifi-cantly improved more than those of control group(P<0.05);the efficiency of depression improvement and nerve function re-covery of observation group was significantly higher than that of control group (P<0.05).Conclusion Antidepressant therapy for stroke patients has exact effect. It can significantly improve depression symptoms ,promote rehabilitation of neurological function and enhance quality of life.