国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2014年
9期
1261-1263
,共3页
宫颈癌%术前%序贯放化疗%同步放化疗%疗效%副作用
宮頸癌%術前%序貫放化療%同步放化療%療效%副作用
궁경암%술전%서관방화료%동보방화료%료효%부작용
Cervical cancer%Preoperative%Sequential chemo-radiotherapy%Concurrent chemo-radiotherapy%Curative effect%Side effect
目的 研究术前序贯放化疗治疗局部巨块型宫颈癌的近期临床疗效.方法 67例Ⅰb2～Ⅱa期局部巨块型(癌灶直径＞4 cm)宫颈癌患者随机分成研究组(35例)和对照组(32例).两组患者术前均给予盆腔外照射放疗,研究组分别于放疗前、后给予TP(紫杉醇+顺铂)方案化疗一程,对照组放疗期间给予顺铂周化疗.比较两组放化疗后近期有效率、手术病理完全缓解率、毒副反应等.结果 研究组放化疗后近期有效率94.28％,对照组96.87％,两组比较差异无统计学意义(P＞0.05).两组均有较明显的骨髓抑制和消化道反应,但患者经治疗后均可耐受.手术病理完全缓解率:研究组14.29％,对照组15.62％,两组比较差异无统计学意义(P＞0.05).结论 巨块型宫颈癌术前序贯放化疗和同步放化疗两者疗效相当.术前序贯放化疗操作更灵活,便于推广,使更多患者受益.
目的 研究術前序貫放化療治療跼部巨塊型宮頸癌的近期臨床療效.方法 67例Ⅰb2～Ⅱa期跼部巨塊型(癌竈直徑＞4 cm)宮頸癌患者隨機分成研究組(35例)和對照組(32例).兩組患者術前均給予盆腔外照射放療,研究組分彆于放療前、後給予TP(紫杉醇+順鉑)方案化療一程,對照組放療期間給予順鉑週化療.比較兩組放化療後近期有效率、手術病理完全緩解率、毒副反應等.結果 研究組放化療後近期有效率94.28％,對照組96.87％,兩組比較差異無統計學意義(P＞0.05).兩組均有較明顯的骨髓抑製和消化道反應,但患者經治療後均可耐受.手術病理完全緩解率:研究組14.29％,對照組15.62％,兩組比較差異無統計學意義(P＞0.05).結論 巨塊型宮頸癌術前序貫放化療和同步放化療兩者療效相噹.術前序貫放化療操作更靈活,便于推廣,使更多患者受益.
목적 연구술전서관방화료치료국부거괴형궁경암적근기림상료효.방법 67례Ⅰb2～Ⅱa기국부거괴형(암조직경＞4 cm)궁경암환자수궤분성연구조(35례)화대조조(32례).량조환자술전균급여분강외조사방료,연구조분별우방료전、후급여TP(자삼순+순박)방안화료일정,대조조방료기간급여순박주화료.비교량조방화료후근기유효솔、수술병리완전완해솔、독부반응등.결과 연구조방화료후근기유효솔94.28％,대조조96.87％,량조비교차이무통계학의의(P＞0.05).량조균유교명현적골수억제화소화도반응,단환자경치료후균가내수.수술병리완전완해솔:연구조14.29％,대조조15.62％,량조비교차이무통계학의의(P＞0.05).결론 거괴형궁경암술전서관방화료화동보방화료량자료효상당.술전서관방화료조작경령활,편우추엄,사경다환자수익.
Objective To study the short-term effect of preoperative sequential chemoradiotherapy in the treatment of local bulky cervical cancer.Methods 67 cases of local bulky cervical cancer at stage Ⅰ b2-Ⅱ a (foci of cancer ＞ 4 cm) were randomly divided into study group (35 cases) and control group (32 cases).All patients received radiotherapy before operation.Study group was given TP model chemotherapy (paclitaxel + cisplatin) before and after radiotherapy,while control group was given eisplatin during radiotherapy.The short-term efficacy,pathologically complete regressiou (PCR) and toxicity of two groups were compared.Results The short-term efficacy of study group was 94.28％,and that of control group was 96.87％,without statistically significant difference betweeu two groups (P ＞ 0.05).There were obvious myelosuppressiou and reaction of digestive tract in two groups,which patients could suffered after treatment.Pathologically complete regression of study group was 14.29％,and that of control group was 15.62％,without statistically significant difference between two groups (P ＞ 0.05).Conclusions Preoperative sequential chemo-radiotherapy has equivalent efficacy to concurrent chemo-radiotherapy in the treatment of bulky cervical cancer.Preoperative sequential chemo-radiotherapy is more flexible in the treatment and will benefit more patients,worthy of promotion.
