CAJ | 학술논문

目的：研究黑蒜联合射波刀（ CyberKnife ）立体精确放疗技术治疗中晚期肝癌患者的临床疗效。方法选择124例中晚期肝癌患者分为2组，对照组60例行单纯Cy-berKnife放疗，观察组64例行黑蒜联合CyberKnife治疗，比较治疗3个月后2组患者影像学指标、肿瘤标志物AFP的改变及ZPS评分的变化。结果治疗3个月后复查CT或PET／CT，对照组肿瘤局部控制有效率71％，观察组为75％，2组近期客观疗效比较无显著性差异（ P＞0．05）；对照组甲胎蛋白（AFP）转为正常或降低9例，治疗有效率为38％，观察组AFP转为正常或降低23例，治疗有效率为64％，2组比较有显著性差异（P＜0．05）；观察组治疗后ZPS评分较治疗前明显改善（P＜0．05），且显著优于对照组（P＜0．05）。结论黑蒜联合CyberKnife治疗中晚期肝癌可明显提高肿瘤局部抑制率和患者ZPS评分，降低肿瘤标志物AFP的表达，改善患者生存质量。
목적：연구흑산연합사파도（ CyberKnife ）입체정학방료기술치료중만기간암환자적림상료효。방법선택124례중만기간암환자분위2조，대조조60례행단순Cy-berKnife방료，관찰조64례행흑산연합CyberKnife치료，비교치료3개월후2조환자영상학지표、종류표지물AFP적개변급ZPS평분적변화。결과치료3개월후복사CT혹PET／CT，대조조종류국부공제유효솔71％，관찰조위75％，2조근기객관료효비교무현저성차이（ P＞0．05）；대조조갑태단백（AFP）전위정상혹강저9례，치료유효솔위38％，관찰조AFP전위정상혹강저23례，치료유효솔위64％，2조비교유현저성차이（P＜0．05）；관찰조치료후ZPS평분교치료전명현개선（P＜0．05），차현저우우대조조（P＜0．05）。결론흑산연합CyberKnife치료중만기간암가명현제고종류국부억제솔화환자ZPS평분，강저종류표지물AFP적표체，개선환자생존질량。
Objective It is to investigate the clinical effect of CyberKnife alone or combined with Aged Black Garlic ( ABG) in advanced refractory liver cancer .Methods 124 patients with advanced liver cancer were divided into two groups , 60 patients in control group were underwent CyberKnife therapy , 64 cases in observe group were received ABG combined with CyberKnife therapy .The changes of radiographic index , expression of AFP and ZPS scores were compared .Results The total effective rate for local tumor control was 75%in observe group and 71%in control group , there was no significant difference (P>0.05).According to the expression of AFP, 9 cases were decreased or became normal in control group , the effective rate was 38%;and 23 cases were decreased or became normal in observe group , the effective rat was 64%;there was significant difference (P<0.05).The ZPS scores were markedly improved in observe group (P<0.05) and significantly better than the control group (P<0.05).Conclusion ABG combine with CyberKnife can markedly improve the short-term outcomes of ad-vanced liver cancer patients , reduce the AFP expression and increase the ZPS scores , and improve the quality of life .