CAJ | 학술논문

目的：研究显微手术治疗对于脑胶质瘤患者认知、生活能力、皮层血流灌注和脑脊液神经肽类物质水平的影响。方法采用显微手术和传统手术分别治疗87例脑胶质瘤患者，采用长谷川智能量表（HDS）、简易精神状态量表（MMSE）和日常生活能力量表（ADL）评估患者认知、生活能力，并检测患者术后皮层血流灌注情况和脑脊液精氨酸加压素（AVP）、催产素（OT）、β-内啡肽（β-EP）、生长抑素（SS）和神经降压素（NT）的水平。结果显微手术患者的 HDS、MMSE和ADL量表评分均显著优于传统手术，且皮层血流灌注丰富，差异均有统计学意义（P＜0．05）；脑脊液中5种神经肽类物质水平也高于传统手术患者，差异有统计学意义（P＜0．05）。结论显微手术能够改善脑胶质瘤患者认知、生活能力，改善脑血流灌注，恢复脑脊液神经肽水平。
목적：연구현미수술치료대우뇌효질류환자인지、생활능력、피층혈류관주화뇌척액신경태류물질수평적영향。방법채용현미수술화전통수술분별치료87례뇌효질류환자，채용장곡천지능량표（HDS）、간역정신상태량표（MMSE）화일상생활능역량표（ADL）평고환자인지、생활능력，병검측환자술후피층혈류관주정황화뇌척액정안산가압소（AVP）、최산소（OT）、β-내배태（β-EP）、생장억소（SS）화신경강압소（NT）적수평。결과현미수술환자적 HDS、MMSE화ADL량표평분균현저우우전통수술，차피층혈류관주봉부，차이균유통계학의의（P＜0．05）；뇌척액중5충신경태류물질수평야고우전통수술환자，차이유통계학의의（P＜0．05）。결론현미수술능구개선뇌효질류환자인지、생활능력，개선뇌혈류관주，회복뇌척액신경태수평。
Objective To explore the effects of microsurgical technique treatment on acknowledge ability ,activities of daily liv-ing ,cortex blood perfusion and neuropeptide levels of brain glioma patients .Methods Microsurgical technique treatment and tradi-tional operation were given to 87 brain glioma patients ,respectively .The acknowledge ability and activities of daily living were measured by HDS ,MMSE and ADL ;the cortex blood perfusion were revealed by PET ,and the neuropeptide levels including argi-nine vasopressin ,oxytocin ,β-endorphin ,somatostatin and neurotensin of patients from two different surgical groups were compared . Results As compared with the traditional operation ,the acknowledge ability and activities of daily living of patients from microsur-gical treatment group were significantly improved(P<0 .05) ,the cortex blood perfusion were statistically increased (P<0 .05) and the levels of five kinds of neuropeptide were all profoundly increased (P< 0 .05) .Conclusion Microsurgical technique treatment could improve the acknowledge ability and activities of daily living of brain glioma patients ,the mechanisms of which could be the increase of cortex blood perfusion and theincrease of neuropeptide levels .