重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
5期
529-531
,共3页
林化%马春林%王荣辉%梁道业
林化%馬春林%王榮輝%樑道業
림화%마춘림%왕영휘%량도업
前白蛋白%C反应蛋白值%载脂蛋白A-Ⅰ%预后%重症肺炎
前白蛋白%C反應蛋白值%載脂蛋白A-Ⅰ%預後%重癥肺炎
전백단백%C반응단백치%재지단백A-Ⅰ%예후%중증폐염
prealbumin%C-reactive protein%apolipoprotein A-Ⅰ%prognosis%severe pneumonia
目的:探讨血清前清蛋白(PAB)、C反应蛋白(CRP)及载脂蛋白 A1(Apo A1)在评估重症肺炎患者预后中的价值。方法选取63例重症肺炎患者,检测入院后24 h内空腹血清PAB、CRP及Apo A1,并计算急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ);按患者APACHE Ⅱ评分值将患者分为两组(<20分为A组,≥20分为B组),分析两组患者多器官功能障碍综合征(MODS)发生率和病死率。将患者分为MODS组及非MODS组,并根据转归将患者分为存活组和死亡组,比较各组患者的血清PAB、CRP及 Apo A1水平的差异。结果 B组 MODS 发生率和病死率(57.9%,47.4%)均显著高于 A 组(24.0%,16.0%),差异有统计学意义(P<0.01,P<0.05)。MODS组[(134.13±36.20) mg/L ,(0.62±0.21)g/L]及死亡组[(129.05±52.24)mg/L ,(0.76±0.29)g/L]PAB、Apo A1分别低于非 MODS组[(215.03±72.08) mg/L ,(1.06±0.39)g/L]及存活组[(185.52±57.63)mg/L ,(1.15±0.36)g/L],差异有统计学意义(P<0.05),而 MODS 组(102.37±35.65)mg/L 及死亡组(96.37±34.72)mg/L CRP分别高于非MODS组(69.68±32.92)mg/L及存活组(62.94±38.36)mg/L (P<0.05)。结论血清PAB、CRP和Apo A1这3种急性时相蛋白对于评估重症肺炎患者病情的危重程度及预后具有一定的价值。
目的:探討血清前清蛋白(PAB)、C反應蛋白(CRP)及載脂蛋白 A1(Apo A1)在評估重癥肺炎患者預後中的價值。方法選取63例重癥肺炎患者,檢測入院後24 h內空腹血清PAB、CRP及Apo A1,併計算急性生理學與慢性健康狀況評分Ⅱ(APACHEⅡ);按患者APACHE Ⅱ評分值將患者分為兩組(<20分為A組,≥20分為B組),分析兩組患者多器官功能障礙綜閤徵(MODS)髮生率和病死率。將患者分為MODS組及非MODS組,併根據轉歸將患者分為存活組和死亡組,比較各組患者的血清PAB、CRP及 Apo A1水平的差異。結果 B組 MODS 髮生率和病死率(57.9%,47.4%)均顯著高于 A 組(24.0%,16.0%),差異有統計學意義(P<0.01,P<0.05)。MODS組[(134.13±36.20) mg/L ,(0.62±0.21)g/L]及死亡組[(129.05±52.24)mg/L ,(0.76±0.29)g/L]PAB、Apo A1分彆低于非 MODS組[(215.03±72.08) mg/L ,(1.06±0.39)g/L]及存活組[(185.52±57.63)mg/L ,(1.15±0.36)g/L],差異有統計學意義(P<0.05),而 MODS 組(102.37±35.65)mg/L 及死亡組(96.37±34.72)mg/L CRP分彆高于非MODS組(69.68±32.92)mg/L及存活組(62.94±38.36)mg/L (P<0.05)。結論血清PAB、CRP和Apo A1這3種急性時相蛋白對于評估重癥肺炎患者病情的危重程度及預後具有一定的價值。
목적:탐토혈청전청단백(PAB)、C반응단백(CRP)급재지단백 A1(Apo A1)재평고중증폐염환자예후중적개치。방법선취63례중증폐염환자,검측입원후24 h내공복혈청PAB、CRP급Apo A1,병계산급성생이학여만성건강상황평분Ⅱ(APACHEⅡ);안환자APACHE Ⅱ평분치장환자분위량조(<20분위A조,≥20분위B조),분석량조환자다기관공능장애종합정(MODS)발생솔화병사솔。장환자분위MODS조급비MODS조,병근거전귀장환자분위존활조화사망조,비교각조환자적혈청PAB、CRP급 Apo A1수평적차이。결과 B조 MODS 발생솔화병사솔(57.9%,47.4%)균현저고우 A 조(24.0%,16.0%),차이유통계학의의(P<0.01,P<0.05)。MODS조[(134.13±36.20) mg/L ,(0.62±0.21)g/L]급사망조[(129.05±52.24)mg/L ,(0.76±0.29)g/L]PAB、Apo A1분별저우비 MODS조[(215.03±72.08) mg/L ,(1.06±0.39)g/L]급존활조[(185.52±57.63)mg/L ,(1.15±0.36)g/L],차이유통계학의의(P<0.05),이 MODS 조(102.37±35.65)mg/L 급사망조(96.37±34.72)mg/L CRP분별고우비MODS조(69.68±32.92)mg/L급존활조(62.94±38.36)mg/L (P<0.05)。결론혈청PAB、CRP화Apo A1저3충급성시상단백대우평고중증폐염환자병정적위중정도급예후구유일정적개치。
Objective To study the value of prealbumin(PAB) ,C reactive protein(CRP) and apolipoprotein A1(Apo A1) in e-valuating the prognosis of patients with severe pneumonia .Methods 63 cases of patients with severe pneumonia were selected ,and the fasting serum level of prealbumin ,C-reactive protein and apolipoprotein A1 were detected in 24 hours at the admission day ,and APACHE Ⅱ score was calcumulated .The patients were divided into group A (APACHEⅡscore <20) and group B(APACHEⅡscore≥20) ,with the incidence of MODS and mortality rate compared .The patients were divided into non-MODS group and MODS group .In addition ,the patients were divided into survival group and death group according to the prognosis .PAB ,CRP and Apo A1 in each group were compared .Results The incidence of MODS and mortality rate in group B (57 .9% ,47 .4% ) were higher than that in group A(24 .0% ,16 .0% )(P<0 .01 ,P<0 .05) .PAB and Apo A1 of patients in MODS group[(134 .13 ± 36 .20)mg/L , (0 .62 ± 0 .21)g/L] and death group[(129 .05 ± 52 .24)mg/L ,(0 .76 ± 0 .29)g/L] were respectively lower than that in non-MODS group[(215 .03 ± 72 .08)mg/L ,(1 .06 ± 0 .39)g/L] and survival group[(185 .52 ± 57 .63)mg/L ,(1 .15 ± 0 .36)g/L](P<0 .05) , while the CRP in MODS group(102 .37 ± 35 .65)mg/L and death group(96 .37 ± 34 .72)mg/L were higher than that in non-MODS group(69 .68 ± 32 .92)mg/L and survival group(62 .94 ± 38 .36)mg/L (P<0 .05) .Conclusion The measurement of PAB ,CRP and Apo A1 are valuable to evaluate the prognosis of the patients with severe pneumonia .