国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2014年
6期
549-553
,共5页
人乳头瘤病毒%基因扩增-导流杂交%基因型%宫颈癌
人乳頭瘤病毒%基因擴增-導流雜交%基因型%宮頸癌
인유두류병독%기인확증-도류잡교%기인형%궁경암
Human papilloma-virus%PCR-HybriMax%Genotype%Cervix cancer
目的 探讨河源地区女性感染人乳头瘤病毒(HPV)基因型分布,为预防HPV感染及临床诊治提供实验依据.方法 采用导流杂交技术对6745例宫颈脱落细胞标本行人乳头瘤病毒(HPV)分型检测.结果 检出HPV感染1 701例,总阳性率为25.20％,其中单一感染1 265例(74.40％),多重感染436例(25.63％),又以二重感染和单独高危型复合感染较为多见.六重感染和九重感染仅见于≤24岁年龄组,50岁以上年龄组均未见五重以上感染.HPV总阳性率、高危型HPV阳性率和低危型HPV阳性率均呈现“U”型特异性分布.受检21种亚型均被检出,常见的3种高危型为HPV52(25.69％)、HPV16(17.34％)和HPV58(15.52％),2种低危型为HPV81 (8.23％)和HPV6 (6.94％).各年龄组中最高感染率型别也有所差异.结论 河源地区受检女性HPV的感染率较高(25.20％),多重感染者占25.63％.HPV总阳性率、高危型HPV阳性率和低危型HPV阳性率的年龄分布存在双峰现象,出现在≥60岁和≤24岁年龄组.最常见亚型是HPV52,不同年龄组HPV感染亚型分布略有不同.
目的 探討河源地區女性感染人乳頭瘤病毒(HPV)基因型分佈,為預防HPV感染及臨床診治提供實驗依據.方法 採用導流雜交技術對6745例宮頸脫落細胞標本行人乳頭瘤病毒(HPV)分型檢測.結果 檢齣HPV感染1 701例,總暘性率為25.20％,其中單一感染1 265例(74.40％),多重感染436例(25.63％),又以二重感染和單獨高危型複閤感染較為多見.六重感染和九重感染僅見于≤24歲年齡組,50歲以上年齡組均未見五重以上感染.HPV總暘性率、高危型HPV暘性率和低危型HPV暘性率均呈現“U”型特異性分佈.受檢21種亞型均被檢齣,常見的3種高危型為HPV52(25.69％)、HPV16(17.34％)和HPV58(15.52％),2種低危型為HPV81 (8.23％)和HPV6 (6.94％).各年齡組中最高感染率型彆也有所差異.結論 河源地區受檢女性HPV的感染率較高(25.20％),多重感染者佔25.63％.HPV總暘性率、高危型HPV暘性率和低危型HPV暘性率的年齡分佈存在雙峰現象,齣現在≥60歲和≤24歲年齡組.最常見亞型是HPV52,不同年齡組HPV感染亞型分佈略有不同.
목적 탐토하원지구녀성감염인유두류병독(HPV)기인형분포,위예방HPV감염급림상진치제공실험의거.방법 채용도류잡교기술대6745례궁경탈락세포표본행인유두류병독(HPV)분형검측.결과 검출HPV감염1 701례,총양성솔위25.20％,기중단일감염1 265례(74.40％),다중감염436례(25.63％),우이이중감염화단독고위형복합감염교위다견.륙중감염화구중감염부견우≤24세년령조,50세이상년령조균미견오중이상감염.HPV총양성솔、고위형HPV양성솔화저위형HPV양성솔균정현“U”형특이성분포.수검21충아형균피검출,상견적3충고위형위HPV52(25.69％)、HPV16(17.34％)화HPV58(15.52％),2충저위형위HPV81 (8.23％)화HPV6 (6.94％).각년령조중최고감염솔형별야유소차이.결론 하원지구수검녀성HPV적감염솔교고(25.20％),다중감염자점25.63％.HPV총양성솔、고위형HPV양성솔화저위형HPV양성솔적년령분포존재쌍봉현상,출현재≥60세화≤24세년령조.최상견아형시HPV52,불동년령조HPV감염아형분포략유불동.
Objective To analysis of the prevalence and genotype distribution of human papilloma-virus (HPV) in Heyuan city.Methods 6745 cases of epithelial cell specimens were subjected HPV subtype screening by HybriMax technology.Results Among the 6745 women,1701 women were HPV positive.The overall prevalence of HPV was 25.20％ (1701/6745).Among the HPV-positive women,74.40％ (1265/1701) were infected with a single HPV type,and 25.63％ (436/1701) were infected with more than one.Infections with double and multiple subtype of HR-HPV was common.Infected with more than six types just were below the age of 24.There were no women infected with more than five type of HPV over the age of 50.We observed a Ushaped age-specific prevalence curve with a first peak over the age of 60 and a second peak below the age of 24 for overall HPV infection,low-risk HPV infection and high-risk HPV infection.The most common subtype was HPV52 (25.69％),followed by HPV16(17.34％)and HPV58(15.52％) in the 15 HR-HPV subtypes,HPV81 (8.23 ％) was the most common subtype in 6 LR-HPV subtypes,followed by HPV6 (6.94％).There is a difference in HPV subtype infection among age groups.Conclusion The high rate of HPV infection is observed in Heyuan city.Multiple HPV infections were identified in 25.63％ of the positive specimens,Two peaks of HPV prevalence were observed in women who were over the age of 60 and below the age of 24 for overall HPV infection,low-risk HPV and high-risk HPV types and the most common subtype was HPV52.There is a difference in HPV subtype infection among age groups.
