CAJ | 학술논문

目的：分析探讨维甲酸、亚砷酸双诱导联合化疗治疗急性早幼粒细胞白血病的临床疗效。方法将41例急性早幼粒细胞白血病患者随机分为观察组22例和对照组19例，观察组给予维甲酸、亚砷酸双诱导联合化疗治疗，对照组采取亚砷酸联合化疗治疗，观察2组的治疗效果。结果观察组患者的症状完全缓解率明显的高于对照组（P<0.05）；观察组病死率低于对照组（P<0.05）；观察组患者的高白细胞血症的持续时间与症状缓解时间均明显的低于对照组，两组比较差异有统计学意义（P<0.05）。结论维甲酸、亚砷酸双诱导联合化疗治疗急性早幼粒细胞白血病临床疗效好，长期生存率高，是急性早幼粒细胞白血病治疗的合理选择之一。
목적：분석탐토유갑산、아신산쌍유도연합화료치료급성조유립세포백혈병적림상료효。방법장41례급성조유립세포백혈병환자수궤분위관찰조22례화대조조19례，관찰조급여유갑산、아신산쌍유도연합화료치료，대조조채취아신산연합화료치료，관찰2조적치료효과。결과관찰조환자적증상완전완해솔명현적고우대조조（P<0.05）；관찰조병사솔저우대조조（P<0.05）；관찰조환자적고백세포혈증적지속시간여증상완해시간균명현적저우대조조，량조비교차이유통계학의의（P<0.05）。결론유갑산、아신산쌍유도연합화료치료급성조유립세포백혈병림상료효호，장기생존솔고，시급성조유립세포백혈병치료적합리선택지일。
Objective To study the therapeutic effect of retinoic acid and arsenious acid induction combined with chemotherapy in newly diagnosed acute promyelocytic leukemia. Methods 41 cases acute promyelocytic leukemia were divided into observation group and control group. 22 cases of observation group were treated with retinoic acid and arsenious acid induction combined with chemotherapy, 19 cases of control group were treated with arsenious oxide combined with chemotherapy. Results The observation group with symptoms of complete remission rate signiifcantly higher than control group(P<0.05) and the mortality rate was also signiifcantly lower than control group (P<0.05) The observation group with high white blood cel viremia duration and symptoms were signiifcantly lower than control group(P<0.05). Conclusion Retinoic acid and arsenious acid induced combined with chemotherapy has a bet er clinical effect in the treatment of newly diagnosed acute promyelocytic leukemia, and the treatment is more accurate and worthy of clinical application.