中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2013年
z1期
9-11
,共3页
噪声%卡托普利%氨氯地平%高血压%血浆肾素活性
譟聲%卡託普利%氨氯地平%高血壓%血漿腎素活性
조성%잡탁보리%안록지평%고혈압%혈장신소활성
Noise%Captopril%Amlodipine%Hypertension%Plasma renin activity
目的 探讨卡托普利联合氨氯地平治疗高度噪声影响下的高血压患者的临床疗效.方法 选择在强度＞ 110dB的噪声条件下工作的高血压患者150例,按随机数字表法分为治疗1组75例和治疗2组75例,治疗1组患者单纯服用卡托普利,治疗2组联合服用卡托普利和氨氯地平,选取75例普通的高血压患者作为对照组,同时服用卡托普利和氨氯地平,服药1年后,比较三组患者的血浆肾素活性(PRA)和临床效果.结果 三组高血压患者的PRA水平和有效率在服药半年比较差异无统计学意义(P＞0.05)；治疗2组在服药1年的血浆PRA水平和有效率与治疗1组比较差异有统计学意义[(1.89±0.37) ng/(ml·h)比(2.40±0.38) ng/(ml·h)、90.67％ (68/75)比72.00％(54/75)](P＜0.05或＜0.01),与对照组比较差异无统计学意义(P＞0.05).结论 在＞110 dB强度的噪声影响下,卡托普利联合氨氯地平控制高血压患者血压的临床效果更为明显,值得临床推广应用.
目的 探討卡託普利聯閤氨氯地平治療高度譟聲影響下的高血壓患者的臨床療效.方法 選擇在彊度＞ 110dB的譟聲條件下工作的高血壓患者150例,按隨機數字錶法分為治療1組75例和治療2組75例,治療1組患者單純服用卡託普利,治療2組聯閤服用卡託普利和氨氯地平,選取75例普通的高血壓患者作為對照組,同時服用卡託普利和氨氯地平,服藥1年後,比較三組患者的血漿腎素活性(PRA)和臨床效果.結果 三組高血壓患者的PRA水平和有效率在服藥半年比較差異無統計學意義(P＞0.05)；治療2組在服藥1年的血漿PRA水平和有效率與治療1組比較差異有統計學意義[(1.89±0.37) ng/(ml·h)比(2.40±0.38) ng/(ml·h)、90.67％ (68/75)比72.00％(54/75)](P＜0.05或＜0.01),與對照組比較差異無統計學意義(P＞0.05).結論 在＞110 dB彊度的譟聲影響下,卡託普利聯閤氨氯地平控製高血壓患者血壓的臨床效果更為明顯,值得臨床推廣應用.
목적 탐토잡탁보리연합안록지평치료고도조성영향하적고혈압환자적림상료효.방법 선택재강도＞ 110dB적조성조건하공작적고혈압환자150례,안수궤수자표법분위치료1조75례화치료2조75례,치료1조환자단순복용잡탁보리,치료2조연합복용잡탁보리화안록지평,선취75례보통적고혈압환자작위대조조,동시복용잡탁보리화안록지평,복약1년후,비교삼조환자적혈장신소활성(PRA)화림상효과.결과 삼조고혈압환자적PRA수평화유효솔재복약반년비교차이무통계학의의(P＞0.05)；치료2조재복약1년적혈장PRA수평화유효솔여치료1조비교차이유통계학의의[(1.89±0.37) ng/(ml·h)비(2.40±0.38) ng/(ml·h)、90.67％ (68/75)비72.00％(54/75)](P＜0.05혹＜0.01),여대조조비교차이무통계학의의(P＞0.05).결론 재＞110 dB강도적조성영향하,잡탁보리연합안록지평공제고혈압환자혈압적림상효과경위명현,치득림상추엄응용.
Objective To observed the clinical efficacy of captopril combined with amlodipine in hypertension patients of the influence of high noise.Methods A total of 150 hypertension patients who worked in ＞ 110 dB noise were divided into treatment group 1 (75 cases) and treatment group 2 (75 cases) by random digits table.Patients simply took enalapril in treatment group 1,patients took enalapril combined with amlodipine in treatment group 2.Selected 75 cases common hypertension patients were control group,they took enalapril combined with amlodipine.A year later,compared with three groups of plasma renin activity (PRA) and clinical efficacy.Results The PRA and efficient rate had no significant difference among three groups in half ayear (P ＞0.05).A year later,the PRA and efficient rate in treatment group 2 and treatment group 1 had obvious difference [(1.89 ± 0.37) ng/ (ml· h) vs.(2.40 ± 0.38) ng/ (ml· h),90.67 ％ (68/75) vs.72.00 ％ (54/75)] (P ＜ 0.05 or ＜ 0.01).But compared with control group no significant difference (P ＞0.05).Conclusion The clinical efficacy of captopril combined with amlodipine in hypertension patients is more apparent.
