CAJ | 학술논문

　　目的探讨阿托伐他汀在老年单纯性收缩期高血压治疗中的临床疗效及对动脉弹性的影响。方法将我院收治的177例老年单纯收缩期高血压患者按照分层随机分组法分为四组，A1组和 A2组为联合用药组，两组均给予阿托伐他汀+氨氯地平，B1组和 B2组为单独用药组，两组均给予氨氯地平，A1和 B1组年龄在60~75岁，A2和 B2组年龄在75岁以上，观察四组患者的临床疗效及动脉弹性指数。结果联合用药组 SBP 达标率、脉压差（PP）、动脉弹性指数及血管内皮功能改善情况显著优于单独用药组，两组间差异有统计学意义（P＜0.05）；A1组 SBP 达标率、PP、动脉弹性指数及血管内皮功能改善情况显著优于 A2组，B1组以上观察指标也显著优于 B2组，不同年龄患者组间差异有统计学意义（P ＜0.05）。结论阿托伐他汀能显著提高临床疗效和改善动脉弹性，不同年龄段患者临床获益率不同，年龄越小获益率越大。
　　목적탐토아탁벌타정재노년단순성수축기고혈압치료중적림상료효급대동맥탄성적영향。방법장아원수치적177례노년단순수축기고혈압환자안조분층수궤분조법분위사조，A1조화 A2조위연합용약조，량조균급여아탁벌타정+안록지평，B1조화 B2조위단독용약조，량조균급여안록지평，A1화 B1조년령재60~75세，A2화 B2조년령재75세이상，관찰사조환자적림상료효급동맥탄성지수。결과연합용약조 SBP 체표솔、맥압차（PP）、동맥탄성지수급혈관내피공능개선정황현저우우단독용약조，량조간차이유통계학의의（P＜0.05）；A1조 SBP 체표솔、PP、동맥탄성지수급혈관내피공능개선정황현저우우 A2조，B1조이상관찰지표야현저우우 B2조，불동년령환자조간차이유통계학의의（P ＜0.05）。결론아탁벌타정능현저제고림상료효화개선동맥탄성，불동년령단환자림상획익솔불동，년령월소획익솔월대。
Objective To explore the clinical efficacy of atorvastatin in the adjuvant treatment of elderly patients with isolated systolic hypertension and the role of arterial elasticity. Methods According to a stratified randomization method, 177 cases of elderly patients with isolated systolic hypertension were divided into the observation group and the control group in our hospital, A1 and A2 groups were given atorvastatin + amlodipine,B1 and B2 group were given amlodipine, A1 and B1 group aged between 60-75 years of age, A2 and B2 group of patients aged 75 years or more, the clinical efficacy and the arterial elasticity index of four groups were observed. Results The combined treatment group was significantly better than the single drug group in the SBP compliance rate, PP,arterial elasticity index and vascular endothelial function, the difference between the two groups was significant(P<0.05); A1 group was significantly better than A2 group in the SBP compliance rate、PP、arterial elasticity index and vascular endothelial function, B1 group also was significantly better than B2 group in the above observations indicators, the difference between the different age groups was significant(P<0.05). Conclusion Atorvastatin can significantly improve the clinical efficacy and improve arterial elasticity, the clinical benefit rate of the different age groups was different, the clinical benefit rate of young patients was higher.