CAJ | 학술논문

目的：探讨2型糖尿病大血管并发症与血清高分子质量脂联素（HMM-ADPN，H-ADPN）水平之间的相关性。方法选取2010年12月至2012年12月接受治疗的106例2型糖尿病患者，分为单纯2型糖尿病组（A组，n＝66）和2型糖尿病合并大血管病变组（B组，n＝40）。测量所有受试者的身高、体质量、血压，同时分别测定高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、三酰甘油（TG）、总胆固醇（TC）、糖化血红蛋白（HbA1c）、空腹血糖（FBG）、高敏C-反应蛋白（hs-CRP）、血清总脂联素（ADPN）、H-ADPN、空腹胰岛素（FINS）、颈动脉内膜中层厚度（CIMT）等。结果两组间血清H-ADPN水平差异有统计学意义（P＜0.05），多因素logistic回归分析显示，调整年龄、性别、体质量指数（BMI）及hs-CRP等因素后血清H-ADPN水平与HDL-C水平呈显著正相关（P＜0.05），与收缩压及CIMT呈负相关（P＜0.05）。结论血清H-ADPN水平在糖尿病动脉粥样硬化过程中可能起重要作用，与2型糖尿病大血管并发症的发生和发展相关。
목적：탐토2형당뇨병대혈관병발증여혈청고분자질량지련소（HMM-ADPN，H-ADPN）수평지간적상관성。방법선취2010년12월지2012년12월접수치료적106례2형당뇨병환자，분위단순2형당뇨병조（A조，n＝66）화2형당뇨병합병대혈관병변조（B조，n＝40）。측량소유수시자적신고、체질량、혈압，동시분별측정고밀도지단백담고순（HDL-C）、저밀도지단백담고순（LDL-C）、삼선감유（TG）、총담고순（TC）、당화혈홍단백（HbA1c）、공복혈당（FBG）、고민C-반응단백（hs-CRP）、혈청총지련소（ADPN）、H-ADPN、공복이도소（FINS）、경동맥내막중층후도（CIMT）등。결과량조간혈청H-ADPN수평차이유통계학의의（P＜0.05），다인소logistic회귀분석현시，조정년령、성별、체질량지수（BMI）급hs-CRP등인소후혈청H-ADPN수평여HDL-C수평정현저정상관（P＜0.05），여수축압급CIMT정부상관（P＜0.05）。결론혈청H-ADPN수평재당뇨병동맥죽양경화과정중가능기중요작용，여2형당뇨병대혈관병발증적발생화발전상관。
Objective To explore the relationship between plasma level of high-molecular-mass adiponectin (HMM-ADPN, H-ADPN) and macrovascular diseases in patients with type 2 diabetes mellitus. Methods A total of 106 patients with type 2 diabetes admitted in our department and Department of Endocrinology from December 2010 to December 2012 were enrolled in this study. These patients were divided into type 2 diabetes group (group A, n=66) and type 2 diabetes accompanied with macrovascular complications group (group B, n=40). Their height, body mass index (BMI), blood pressure and high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TG), total cholesterol (TC), hemoglobin A1c (HbA1c), fasting blood glucose (FBG), fasting insulin (FINS), high-sensitivity C reactive protein (hs-CRP), total-adiponectin (ADPN), H-ADPN, carotid intima-media thickness (CIMT) and other indices were measured and calculated. And the results were compared between the 2 groups. Results Plasma H-ADPN was significantly lower in group B than in group A (P<0.05). Multivariate regression analysis revealed that serum level of H-ADPN level was positively correlated with that of HDL-C (P<0.05), but was negatively correlated with systolic blood pressure and CIMT (P<0.05) after adjustment for age, gender, BMI and hs-CRP. Conclusion Plasma H-ADPN level might play an important role in the atherosclerosis in type 2 diabetes patients, and be involved in the incidence and development of macrovascular complications in them.