中华老年多器官疾病杂志
中華老年多器官疾病雜誌
중화노년다기관질병잡지
CHINESE JOURNAL OF MULTIPLE ORGAN DISEASES IN THE ELDERLY
2014年
3期
170-173
,共4页
虞阳%于晓峰%严晶璐%姚健凤
虞暘%于曉峰%嚴晶璐%姚健鳳
우양%우효봉%엄정로%요건봉
便秘%焦虑%老年人%乳果糖
便祕%焦慮%老年人%乳果糖
편비%초필%노년인%유과당
constipation%anxiety%aged%lactulose
目的:观察乳果糖联合氟哌噻吨/美利曲辛对伴有轻中度焦虑状态老年便秘患者治疗后的便秘、焦虑状态改善情况,以及不良反应的发生率。方法选择2011年1月至2012年12月在复旦大学附属华东医院门诊治疗的80例伴有轻中度焦虑状态老年便秘患者[年龄65~86(74.6±7.6)岁],随机分为治疗组和对照组,治疗组口服氟哌噻吨/美利曲辛片1片,1次/d,同时给予乳果糖口服液15ml,2次/d;对照组单纯给予乳果糖口服液15ml,2次/d,疗程均为4周。分别在第2周和第4周记录患者便秘治疗的有效率以及焦虑自评量表(SAS)评分变化情况。结果两组患者在治疗4周后便秘状况均得到改善,但在治疗2周时,治疗组患者的总有效率高于对照组,差异有统计学意义(P=0.029);治疗2周和4周时,治疗组患者的SAS评分降低值与对照组比较,差异均具有统计学意义(P=0.020,P=0.012)。两组患者均未出现严重不良反应,两组间不良反应发生率差异无统计学意义(P>0.05)。结论乳果糖合并氟哌噻吨/美利曲辛治疗伴有轻中度焦虑状态的功能性便秘老年患者是有效且安全的。
目的:觀察乳果糖聯閤氟哌噻噸/美利麯辛對伴有輕中度焦慮狀態老年便祕患者治療後的便祕、焦慮狀態改善情況,以及不良反應的髮生率。方法選擇2011年1月至2012年12月在複旦大學附屬華東醫院門診治療的80例伴有輕中度焦慮狀態老年便祕患者[年齡65~86(74.6±7.6)歲],隨機分為治療組和對照組,治療組口服氟哌噻噸/美利麯辛片1片,1次/d,同時給予乳果糖口服液15ml,2次/d;對照組單純給予乳果糖口服液15ml,2次/d,療程均為4週。分彆在第2週和第4週記錄患者便祕治療的有效率以及焦慮自評量錶(SAS)評分變化情況。結果兩組患者在治療4週後便祕狀況均得到改善,但在治療2週時,治療組患者的總有效率高于對照組,差異有統計學意義(P=0.029);治療2週和4週時,治療組患者的SAS評分降低值與對照組比較,差異均具有統計學意義(P=0.020,P=0.012)。兩組患者均未齣現嚴重不良反應,兩組間不良反應髮生率差異無統計學意義(P>0.05)。結論乳果糖閤併氟哌噻噸/美利麯辛治療伴有輕中度焦慮狀態的功能性便祕老年患者是有效且安全的。
목적:관찰유과당연합불고새둔/미리곡신대반유경중도초필상태노년편비환자치료후적편비、초필상태개선정황,이급불량반응적발생솔。방법선택2011년1월지2012년12월재복단대학부속화동의원문진치료적80례반유경중도초필상태노년편비환자[년령65~86(74.6±7.6)세],수궤분위치료조화대조조,치료조구복불고새둔/미리곡신편1편,1차/d,동시급여유과당구복액15ml,2차/d;대조조단순급여유과당구복액15ml,2차/d,료정균위4주。분별재제2주화제4주기록환자편비치료적유효솔이급초필자평량표(SAS)평분변화정황。결과량조환자재치료4주후편비상황균득도개선,단재치료2주시,치료조환자적총유효솔고우대조조,차이유통계학의의(P=0.029);치료2주화4주시,치료조환자적SAS평분강저치여대조조비교,차이균구유통계학의의(P=0.020,P=0.012)。량조환자균미출현엄중불량반응,량조간불량반응발생솔차이무통계학의의(P>0.05)。결론유과당합병불고새둔/미리곡신치료반유경중도초필상태적공능성편비노년환자시유효차안전적。
Objective To observe the effect and adverse reactions of flupentixol/melitracen combined with lactulose on constipation and anxiety status in the elderly constipated patients with mild to moderate anxiety. Methods Eighty elderly constipated out-patients [aged (74.6±7.6) years] suffering from mild to moderate anxiety in our department from January 2011 to December 2012 were recruited in this study. They were randomly divided into treatment group and control group. The patients in treatment group were treated with flupenthixol melitracen tablets 1qd, and lactulose 15ml bid, while the patients in control group were given lactulose 15ml bid only. The regimen of treatment lasted for 4 weeks in both groups. The effective rate and self-rating anxiety scale (SAS) score was measured and recorded at the 2nd and 4th weeks after treatment. Results The constipation symptoms were alleviated in the 2 groups at the end of treatment. The total effective rate after 2 weeks treatment was significantly higher in the treatment group than in control group (P=0.029). The SAS scores were decreased more significantly in the treatment group than in the control group at the 2nd and 4th week (P=0.020, P=0.012). No serious adverse reaction was found in the 2 groups of patients. The incidence of adverse reactions had no statistical difference between the 2 groups (P>0.05). Conclusion Flupentixol/melitracen combined with lactulose is effective and safe in the treatment of functional constipation in the elderly patients with mild to moderate anxiety.