中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2014年
3期
444-447
,共4页
肺肿瘤%角蛋白质类%p63%病理参数%相关分析
肺腫瘤%角蛋白質類%p63%病理參數%相關分析
폐종류%각단백질류%p63%병리삼수%상관분석
Lung neoplasms%Keratins%p63%Pathological parameters%Correlation analysis
目的:探讨p63蛋白和CK5/6在肺癌组织中的表达及其与临床病理的关系。方法应用免疫组化SP法分别检测106例肺癌组织中p63和CK5/6蛋白质的表达并对结果进行分析。结果 p63在肺癌中阳性表达率为54.72%(58/106),其中在肺鳞癌中的阳性表达率(84.09%)明显高于在腺癌中的(23.26%)(P<0.05);CK5/6在肺癌中阳性表达率为43.40%(46/106),其中CK5/6在肺鳞癌中的阳性表达率(77.27%)明显高于在腺癌中的(9.30%)(P<0.05)。在不同年龄、不同分化程度、不同临床分期以及有无淋巴结转移的肺癌患者中,p63和CK5/6阳性表达率均无显著性差异(P>0.05)。肺癌组织中p63表达与CK5/6表达呈正相关(rs=0.628,P=0.01)。结论 p63、CK5/6的表达与肺癌病理类型密切相关,二者在肺癌中的表达密切相关。
目的:探討p63蛋白和CK5/6在肺癌組織中的錶達及其與臨床病理的關繫。方法應用免疫組化SP法分彆檢測106例肺癌組織中p63和CK5/6蛋白質的錶達併對結果進行分析。結果 p63在肺癌中暘性錶達率為54.72%(58/106),其中在肺鱗癌中的暘性錶達率(84.09%)明顯高于在腺癌中的(23.26%)(P<0.05);CK5/6在肺癌中暘性錶達率為43.40%(46/106),其中CK5/6在肺鱗癌中的暘性錶達率(77.27%)明顯高于在腺癌中的(9.30%)(P<0.05)。在不同年齡、不同分化程度、不同臨床分期以及有無淋巴結轉移的肺癌患者中,p63和CK5/6暘性錶達率均無顯著性差異(P>0.05)。肺癌組織中p63錶達與CK5/6錶達呈正相關(rs=0.628,P=0.01)。結論 p63、CK5/6的錶達與肺癌病理類型密切相關,二者在肺癌中的錶達密切相關。
목적:탐토p63단백화CK5/6재폐암조직중적표체급기여림상병리적관계。방법응용면역조화SP법분별검측106례폐암조직중p63화CK5/6단백질적표체병대결과진행분석。결과 p63재폐암중양성표체솔위54.72%(58/106),기중재폐린암중적양성표체솔(84.09%)명현고우재선암중적(23.26%)(P<0.05);CK5/6재폐암중양성표체솔위43.40%(46/106),기중CK5/6재폐린암중적양성표체솔(77.27%)명현고우재선암중적(9.30%)(P<0.05)。재불동년령、불동분화정도、불동림상분기이급유무림파결전이적폐암환자중,p63화CK5/6양성표체솔균무현저성차이(P>0.05)。폐암조직중p63표체여CK5/6표체정정상관(rs=0.628,P=0.01)。결론 p63、CK5/6적표체여폐암병리류형밀절상관,이자재폐암중적표체밀절상관。
Objective To detect the expression of p63 and CK5/6 in lung cancer and to evaluate their clinical significance. Methods The expression of p63 and CK5/6 from 106 lung cancer tissue specimens were detected by immunohistochemical S-P method, together with their clinicopathologic data. Results The positive rate p63 protein in lung cancer was 54.72%(58/106). The positive rate of p63 protein in squamous cell lung cancinoma (84.09%) was higher than that in adenocarcinoma(23.26%)(P<0.05). The positive rate CK5/6 protein in lung cancer was 43.40%(46/106). the positive rate of CK5/6 protein in squamous cell lung cancinoma (77.27%) was higher than that in adenocarcinoma(9.30%)(P<0.05). The expression of p63 and CK5/6 protein was negatively correlated with age, lymph node metastasis, degree of differentiation and clinical staging of lung cancer (P>0.05). and the expression of p63 and CK5/6 protein was correlated with the expression of CK5/6 protein (rs=0.628, P=0.01). Conclusion p63 and CK5/6 may be a useful panel for the identification and differential of lung cancer.