CAJ | 학술논문

目的：探讨急性脑出血患者血清炎症因子和氧化应激产物的动态变化及临床意义。方法测定180例健康对照者及180例急性脑出血患者发病24 h内、3 d、7 d及14 d时血清TNF-α、IL-1β、IL-6、IL-8、超氧化物歧化酶、丙二醛和总抗氧化能力的含量，并分别将以上指标与急性脑出血出血量大小、病情严重程度进行相关性分析，利用ROC曲线分析其对急性脑出血恶化的临床预测意义。结果急性脑出血患者不同时期内血清 TNF-α、IL-1β、IL-6、IL-8、超氧化物歧化酶、丙二醛含量均高于正常对照组，而总抗氧化能力含量则低于正常对照组；血清TNF-α、IL-1β、IL-6、IL-8和超氧化物歧化酶、丙二醛血清浓度与患者脑出血量大小、病情严重程度呈正性相关，总抗氧化能力呈显著负相关；炎症因子和氧化应激产物的血清浓度对急性脑出血恶化具有显著的预测价值。结论血清炎症因子和氧化应激产物参与了脑出血的病理生理过程，对于患者病情控制、预后改善具有重要临床意义。
목적：탐토급성뇌출혈환자혈청염증인자화양화응격산물적동태변화급림상의의。방법측정180례건강대조자급180례급성뇌출혈환자발병24 h내、3 d、7 d급14 d시혈청TNF-α、IL-1β、IL-6、IL-8、초양화물기화매、병이철화총항양화능력적함량，병분별장이상지표여급성뇌출혈출혈량대소、병정엄중정도진행상관성분석，이용ROC곡선분석기대급성뇌출혈악화적림상예측의의。결과급성뇌출혈환자불동시기내혈청 TNF-α、IL-1β、IL-6、IL-8、초양화물기화매、병이철함량균고우정상대조조，이총항양화능력함량칙저우정상대조조；혈청TNF-α、IL-1β、IL-6、IL-8화초양화물기화매、병이철혈청농도여환자뇌출혈량대소、병정엄중정도정정성상관，총항양화능력정현저부상관；염증인자화양화응격산물적혈청농도대급성뇌출혈악화구유현저적예측개치。결론혈청염증인자화양화응격산물삼여료뇌출혈적병리생리과정，대우환자병정공제、예후개선구유중요림상의의。
Objective To investigate the change of inflammatory cytokines and products of oxidative stress in the patients with acute cerebral hemorrhage and its clinical significance. Methods TNF-α, IL-1β, IL-6, IL-8, SOD, MDA and T-AOC were measured in 180 healthy persons and 180 patients after the onset of ACH at 24 h, 3 d, 7 d and 14 d. Correlation analyzes were performed respectively between bleeding quantity or serious degree in patients with ACH and the above indicators. ROC curve was exploited to analysis its clinical prediction significance to the deterioration of ACH. Results TNF-α, IL-1β, IL-6, IL-8, SOD and MDA in ACH patients were higher than those in healthy controls, and T-AOC was lower;There was a positive correlation between brain bleeding quantity or severity and the contents of TNF-α, IL-1β, IL-6, IL-8, SOD and MDA in ACH patients. There was a negative correlation between the size of brain bleeding or serious degree and the contents of T-AOC. The inflammatory cytokines and products of oxidative stress in the patients had its clinical prediction significance to the deterioration of ACH. Conclusions The inflammatory cytokines and products of oxidative stress can participate in the severity of the brain edema in ACH patients. It has important clinical significance for patients with disease control and improved prognosis.