中国医学前沿杂志（电子版）
中國醫學前沿雜誌（電子版）
중국의학전연잡지（전자판）
CHINESE JOURNAL OF THE FRONTIERS OF MEDICAL SCIENCE(ELECTRONIC VERSION)
2014年
3期
35-38
,共4页
刘春秋%李国欢%赵洪焕%王翠兰%韩素桂%杨俊泉
劉春鞦%李國歡%趙洪煥%王翠蘭%韓素桂%楊俊泉
류춘추%리국환%조홍환%왕취란%한소계%양준천
p53%肺癌%放疗
p53%肺癌%放療
p53%폐암%방료
Serum p53 antibodies%Lung cancer%Radiotherapy
目的探讨92例非小细胞肺癌患者血清p53抗体和临床病理特征之间的关系及放化治疗期间p53抗体的变化。方法治疗前检测92例非小细胞肺癌患者和50名健康人血清p53抗体水平，92例非小细胞肺癌患者在放疗剂量为20 Gy/（10 f·12 d），40 Gy/（20 f·26 d）和60 Gy/（30 f·36 d）下，检测p53抗体水平。结果92例非小细胞肺癌患者血清p53抗体阳性率明显高于正常人（P＜0.05）。非小细胞肺癌患者p53抗体阳性率与分化程度、疾病分期、肿块大小，淋巴结转移有相关性（P＜0.05），与性别，年龄，肿块的位置无显著相关性（P＞0.05）。放疗剂量40 Gy/（20 f·26 d）和60 Gy/（30 f·40 d）， p53抗体阳性率存在显著差异（P＜0.05）。p53抗体高表达的癌症患者治疗疗效较p53抗体阴性患者治疗疗效差。结论放疗前后对血清p53抗体连续变化的监测，对评估非小细胞肺癌患者治疗和预后有帮助。
目的探討92例非小細胞肺癌患者血清p53抗體和臨床病理特徵之間的關繫及放化治療期間p53抗體的變化。方法治療前檢測92例非小細胞肺癌患者和50名健康人血清p53抗體水平，92例非小細胞肺癌患者在放療劑量為20 Gy/（10 f·12 d），40 Gy/（20 f·26 d）和60 Gy/（30 f·36 d）下，檢測p53抗體水平。結果92例非小細胞肺癌患者血清p53抗體暘性率明顯高于正常人（P＜0.05）。非小細胞肺癌患者p53抗體暘性率與分化程度、疾病分期、腫塊大小，淋巴結轉移有相關性（P＜0.05），與性彆，年齡，腫塊的位置無顯著相關性（P＞0.05）。放療劑量40 Gy/（20 f·26 d）和60 Gy/（30 f·40 d）， p53抗體暘性率存在顯著差異（P＜0.05）。p53抗體高錶達的癌癥患者治療療效較p53抗體陰性患者治療療效差。結論放療前後對血清p53抗體連續變化的鑑測，對評估非小細胞肺癌患者治療和預後有幫助。
목적탐토92례비소세포폐암환자혈청p53항체화림상병리특정지간적관계급방화치료기간p53항체적변화。방법치료전검측92례비소세포폐암환자화50명건강인혈청p53항체수평，92례비소세포폐암환자재방료제량위20 Gy/（10 f·12 d），40 Gy/（20 f·26 d）화60 Gy/（30 f·36 d）하，검측p53항체수평。결과92례비소세포폐암환자혈청p53항체양성솔명현고우정상인（P＜0.05）。비소세포폐암환자p53항체양성솔여분화정도、질병분기、종괴대소，림파결전이유상관성（P＜0.05），여성별，년령，종괴적위치무현저상관성（P＞0.05）。방료제량40 Gy/（20 f·26 d）화60 Gy/（30 f·40 d）， p53항체양성솔존재현저차이（P＜0.05）。p53항체고표체적암증환자치료료효교p53항체음성환자치료료효차。결론방료전후대혈청p53항체련속변화적감측，대평고비소세포폐암환자치료화예후유방조。
Objective To explore the relationship between p53 antibody and clinical and pathological characteristics in 92 cases of patients with non small cell lung cancer, and to investigate Chang of P53 antibody. Methods The serum p53-Ab levels were detected in 92 cases of patients with non small cell lung cancer and 50 healthy adults The blood samples were collected on the day before radiotherapy and on the administration of an irradiation dose of 20 Gy/(10 f·12 d), 40 Gy/(20 f·26 d) and 60 Gy/(30 f·36 d) after radiotherapy. Results The level and positive rate of serum p53-Abs in 92 cases of patients with non small cell lung cancer were signiifcantly higher than those innormal individuals (P<0.05) The positive rate of p53-Abs in 92 cases of patients with non small cell lung cancer was related to Tumor differentiation, disease stage the size of tumor and lymph node metastasis (P<0.05), but it was not signiifcantly related to sex, age and site of tumor . The level and positive ratof p53-Abs had signiifcant differences between before radiotherapy and after administration of an irradiation dose of 40 Gy/(20 f·26 d) and 60 Gy/(30 f·36 d) (P<0.05). The positive rate of p53-Abs in tumor patients with effect was significantly lower than that in thosewithout effect after radiotherapy. Conclusion Detection of serum p53-Abs is helpful to the patients with non small cell lung cancer Monitoring for sequential change of serum p53-Abs before and after radiotherapy in patients with patients with non small cell lung cancer is also useful to evaluate the response to the treatment and prognosis of the patients.
