国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2013年
10期
784-789
,共6页
脂联素%肺癌%侵袭%转移%炎症%血管生成
脂聯素%肺癌%侵襲%轉移%炎癥%血管生成
지련소%폐암%침습%전이%염증%혈관생성
Adiponectin%Lung cancer%Invasion%Metastasis%Inflammation%Angiogenesis
脂联素(Acrp30)是1996年由Sherer发现的一种内源性生物活性多肽,可通过AMPK、PI3K/Akt/mTOR、JNK-START-3、Wnt-β-catenin等信号通路选择性地抑制乳腺癌、前列腺癌、卵巢癌等多种恶性肿瘤细胞增殖、侵袭转移、炎性反应及血管生成.脂联素与肺癌的病理分期、炎症反应、血管生成密切相关,但脂联素在肺癌等多种癌症中的作用及作用机制目前仍存较多争议,进一步探明脂联素与肺癌的增殖、侵袭、转移及血管生成的关系可为治疗肺癌提供新的思路.
脂聯素(Acrp30)是1996年由Sherer髮現的一種內源性生物活性多肽,可通過AMPK、PI3K/Akt/mTOR、JNK-START-3、Wnt-β-catenin等信號通路選擇性地抑製乳腺癌、前列腺癌、卵巢癌等多種噁性腫瘤細胞增殖、侵襲轉移、炎性反應及血管生成.脂聯素與肺癌的病理分期、炎癥反應、血管生成密切相關,但脂聯素在肺癌等多種癌癥中的作用及作用機製目前仍存較多爭議,進一步探明脂聯素與肺癌的增殖、侵襲、轉移及血管生成的關繫可為治療肺癌提供新的思路.
지련소(Acrp30)시1996년유Sherer발현적일충내원성생물활성다태,가통과AMPK、PI3K/Akt/mTOR、JNK-START-3、Wnt-β-catenin등신호통로선택성지억제유선암、전렬선암、란소암등다충악성종류세포증식、침습전이、염성반응급혈관생성.지련소여폐암적병리분기、염증반응、혈관생성밀절상관,단지련소재폐암등다충암증중적작용급작용궤제목전잉존교다쟁의,진일보탐명지련소여폐암적증식、침습、전이급혈관생성적관계가위치료폐암제공신적사로.
Adiponectin (Acrp30),a kind of endogenous bioactive peptides found by Sherer in 1996,could selectively inhibit the proliferation,invasion or metastasis,inflammatory response and angiogenesis of various malignant tumors including breast cancer,prostate cancer,and ovarian cancer through different signaling pathways such as AMPK,PI3K/Akt/mTOR,JNK-START-3,Wnt-β-catenin signaling pathways.Adiponectin is greatly related to pathological stages,inflammatory reactions,angiogenesis of lung cancer.However,the detailed effects and its mechanisms of adiponectin in lung tumor and other tumors have not been stressed,and exploring the specific role of adiponectin in lung cancer may provide new ideas for the treatment of lung cancer.
