CAJ | 학술논문

背景与目的：背景抑制扩散加权成像(diffusion-weighted whole-body imaging with background body signal suppression，DWIBS)是一种可用于全身检查的MR成像技术，可以较好地显示淋巴结及骨骼系统病变，其成像效果与PET类似。本研究旨在探讨DWIBS与核素骨扫描成像在骨转移性病变诊断中的临床应用价值。方法：36例经手术或穿刺病理证实为恶性肿瘤的患者行DWIBS及核素骨扫描检查，比较两者检出骨转移的情况，采用χ2检验，P＜0.05为差异有统计学意义。结果：36例恶性肿瘤患者中，30例(共165处)发生骨转移，其中DWIBS检出26例(143处)，核素骨扫描检出23例(132处)，两者在检出骨转移方面差异无统计学意义(χ2=1.002，P=0.506)。DWIBS及核素骨扫描诊断骨转移的灵敏度、阳性预测值、准确度较为接近，分别为86.7%、96.3%、86.1%和76.7%、88.5%、72.2%；DWIBS诊断骨转移的特异度、阴性预测值高于核素骨扫描，分别为83.3%、55.6%和50.0%、30.0%。分析DWIBS和核素骨扫描检出骨转移的部位，两者的检出率分别为86.7%(143/165)、80.0%(132/165)，差异无统计学意义(χ2=2.640，P=0.104)；但DWIBS在检出骨盆及四肢长骨转移方面优于核素骨扫描，且两者差异均有统计学意义(χ2=6.783和7.636，P=0.023和0.016)。结论：运用DWIBS扫描技术可有效检出骨转移性病灶，且与核素骨扫描具有较好的一致性，有望在临床上推广应用。
배경여목적：배경억제확산가권성상(diffusion-weighted whole-body imaging with background body signal suppression，DWIBS)시일충가용우전신검사적MR성상기술，가이교호지현시림파결급골격계통병변，기성상효과여PET유사。본연구지재탐토DWIBS여핵소골소묘성상재골전이성병변진단중적림상응용개치。방법：36례경수술혹천자병리증실위악성종류적환자행DWIBS급핵소골소묘검사，비교량자검출골전이적정황，채용χ2검험，P＜0.05위차이유통계학의의。결과：36례악성종류환자중，30례(공165처)발생골전이，기중DWIBS검출26례(143처)，핵소골소묘검출23례(132처)，량자재검출골전이방면차이무통계학의의(χ2=1.002，P=0.506)。DWIBS급핵소골소묘진단골전이적령민도、양성예측치、준학도교위접근，분별위86.7%、96.3%、86.1%화76.7%、88.5%、72.2%；DWIBS진단골전이적특이도、음성예측치고우핵소골소묘，분별위83.3%、55.6%화50.0%、30.0%。분석DWIBS화핵소골소묘검출골전이적부위，량자적검출솔분별위86.7%(143/165)、80.0%(132/165)，차이무통계학의의(χ2=2.640，P=0.104)；단DWIBS재검출골분급사지장골전이방면우우핵소골소묘，차량자차이균유통계학의의(χ2=6.783화7.636，P=0.023화0.016)。결론：운용DWIBS소묘기술가유효검출골전이성병조，차여핵소골소묘구유교호적일치성，유망재림상상추엄응용。
Background and purpose:Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS) can be used for MR imaging systemic examination, especially the lymph node and bone diseases can be clear, and the imaging result is similar with PET. The aim of this study was to compare the value of clinical application in the diagnosis of malignant metastatic osteopathic between DWIBS and bone scintigraphy mapping. Methods:Thirty-six specimens conifrmed with malignant tumors by the pathology of operation or biopsy underwent both DWIBS imaging and bone scintigraphy mapping, chi-square test was used for comparing the detection results of bone metastasis by this two imaging methods. Results:Thirty (165 positions in all) of 36 malignant tumor patients were conifrmed as having bone metastasis, compared that 26 patients (143 positions) with DWIBS method and 23 patients (132 positions) with bone scintigraphy mapping were detected, but there was no statistical signiifcance between this two imaging methods (χ2=1.002, P=0.506). The sensitivity, positive predictive value (PPV) and accuracy of the detection rate of bone metastasis were similar in DWIBS and bone scintigraphy, with 86.7%, 96.3%, 86.1%and 76.7%, 88.5%, 72.2%, respectively;but the speciifcity and negative predictive value (NPV) in DWIBS (83.3%and 55.6%) was higher than that of in bone scintigraphy (50.0%and 30.0%). The detection rates of different bone metastasis with DWIBS and bone scintigraphy were 86.7%(143/165) and 80.0%(132/165), and it was no signiifcant difference (χ2=2.640, P=0.104);DWIBS method was better than bone scintigraphy in the detection of osseous metastasis on pelvis and limbs long bone, and there was different signiifcant (χ2=6.783 and 7.636, P=0.023 and 0.016). Conclusion:DWIBS could detect bone metastatic lesions effectively, and there is ifne consistency with bone scintigraphy. Therefore, DWIBS is to hope to be extended and applicated clinically.