临床肿瘤学杂志
臨床腫瘤學雜誌
림상종류학잡지
CHINESE CLINICAL ONCOLOGY
2014年
3期
221-225
,共5页
郑云燕%陈陆俊%徐斌%蒋敬庭%吴昌平
鄭雲燕%陳陸俊%徐斌%蔣敬庭%吳昌平
정운연%진륙준%서빈%장경정%오창평
B7-H1%皮肤恶性肿瘤%免疫组织化学%共刺激分子
B7-H1%皮膚噁性腫瘤%免疫組織化學%共刺激分子
B7-H1%피부악성종류%면역조직화학%공자격분자
B7-H1%Malignant cutaneous tumor%Immunochemistry%Costimulatory molecules
目的:研究共刺激分子B7-H1在常见皮肤恶性肿瘤组织中的表达及其临床意义。方法采用ElivsionTM plus免疫组织化学法检测B7-H1在51例鳞状细胞癌( SCC组)和93例非鳞状细胞癌共144例皮肤恶性肿瘤组织中的表达情况,同时选取10例日光性角化病(癌前病变组)和10例皮肤良性肿瘤(良性肿瘤组)作对照,分析B7-H1在癌前病变组、良性肿瘤组、SCC组及非鳞状细胞癌中的阳性表达率以及SCC中B7-H1表达水平与临床病理参数(年龄、性别、肿瘤大小、肿瘤部位、曝光部位及分化程度)间的关系。结果 B7-H1主要表达于皮肤肿瘤细胞的胞质及胞膜,呈弥漫性棕黄色颗粒状染色。B7-H1在癌前病变组、良性肿瘤组及SCC组的阳性表达率分别为10?0%(1/10)、40?0%(4/10)和76?5%(39/51);在SCC中, B7-H1表达水平在不同年龄、性别、肿瘤大小、肿瘤部位、曝光部位及分化程度间的差异均无统计学意义( P>0?05)。 B7-H1在常见上皮来源的非鳞状细胞癌中均有表达,其中基底细胞癌、汗腺癌、乳房外Paget病、腺样囊性癌、皮脂腺癌及恶性黑色素瘤的阳性表达率依次为81?4%(35/43)、70?0%(7/10)、100?0%(3/3)、100?0%(2/2)、100?0%(1/1)和76?2%(16/21)。而在非上皮来源的隆突性纤维肉瘤中未见表达。结论皮肤SCC组织中B7-H1表达率高于癌前病变和皮肤良性肿瘤组织,提示B7-H1可能参与了皮肤恶性肿瘤的发生与发展。
目的:研究共刺激分子B7-H1在常見皮膚噁性腫瘤組織中的錶達及其臨床意義。方法採用ElivsionTM plus免疫組織化學法檢測B7-H1在51例鱗狀細胞癌( SCC組)和93例非鱗狀細胞癌共144例皮膚噁性腫瘤組織中的錶達情況,同時選取10例日光性角化病(癌前病變組)和10例皮膚良性腫瘤(良性腫瘤組)作對照,分析B7-H1在癌前病變組、良性腫瘤組、SCC組及非鱗狀細胞癌中的暘性錶達率以及SCC中B7-H1錶達水平與臨床病理參數(年齡、性彆、腫瘤大小、腫瘤部位、曝光部位及分化程度)間的關繫。結果 B7-H1主要錶達于皮膚腫瘤細胞的胞質及胞膜,呈瀰漫性棕黃色顆粒狀染色。B7-H1在癌前病變組、良性腫瘤組及SCC組的暘性錶達率分彆為10?0%(1/10)、40?0%(4/10)和76?5%(39/51);在SCC中, B7-H1錶達水平在不同年齡、性彆、腫瘤大小、腫瘤部位、曝光部位及分化程度間的差異均無統計學意義( P>0?05)。 B7-H1在常見上皮來源的非鱗狀細胞癌中均有錶達,其中基底細胞癌、汗腺癌、乳房外Paget病、腺樣囊性癌、皮脂腺癌及噁性黑色素瘤的暘性錶達率依次為81?4%(35/43)、70?0%(7/10)、100?0%(3/3)、100?0%(2/2)、100?0%(1/1)和76?2%(16/21)。而在非上皮來源的隆突性纖維肉瘤中未見錶達。結論皮膚SCC組織中B7-H1錶達率高于癌前病變和皮膚良性腫瘤組織,提示B7-H1可能參與瞭皮膚噁性腫瘤的髮生與髮展。
목적:연구공자격분자B7-H1재상견피부악성종류조직중적표체급기림상의의。방법채용ElivsionTM plus면역조직화학법검측B7-H1재51례린상세포암( SCC조)화93례비린상세포암공144례피부악성종류조직중적표체정황,동시선취10례일광성각화병(암전병변조)화10례피부량성종류(량성종류조)작대조,분석B7-H1재암전병변조、량성종류조、SCC조급비린상세포암중적양성표체솔이급SCC중B7-H1표체수평여림상병리삼수(년령、성별、종류대소、종류부위、폭광부위급분화정도)간적관계。결과 B7-H1주요표체우피부종류세포적포질급포막,정미만성종황색과립상염색。B7-H1재암전병변조、량성종류조급SCC조적양성표체솔분별위10?0%(1/10)、40?0%(4/10)화76?5%(39/51);재SCC중, B7-H1표체수평재불동년령、성별、종류대소、종류부위、폭광부위급분화정도간적차이균무통계학의의( P>0?05)。 B7-H1재상견상피래원적비린상세포암중균유표체,기중기저세포암、한선암、유방외Paget병、선양낭성암、피지선암급악성흑색소류적양성표체솔의차위81?4%(35/43)、70?0%(7/10)、100?0%(3/3)、100?0%(2/2)、100?0%(1/1)화76?2%(16/21)。이재비상피래원적륭돌성섬유육류중미견표체。결론피부SCC조직중B7-H1표체솔고우암전병변화피부량성종류조직,제시B7-H1가능삼여료피부악성종류적발생여발전。
Objective To explore the expressions of costimulatory molecule B7-H1 in malignant cutaneous tumor tissues and their clinical significance. Methods The expressions of B7-H1 were detected by ElivsionTM plus immunohistochemical technique in tumor tissues from 51 patients with squamous cell carcinoma ( SCC group) and 93 patients with non-squamous cell carcinoma. Tissues obtained from 10 patients with actinic keratosis ( precancerous lesions group) and 10 patients with benign cutaneous tumors ( benign tumor group) were chosen as control. The positive rates of B7-H1 in precancerous lesions group, benign tumor group, SCC group and non-squamous cell carcinoma were analyzed. The relationships between expressions of B7-H1 and clinicopathological characteristics ( age, sex, tumor size, tumor location, exposure, location and degree of differentiation) in SCC were investigated. Results The B7-H1 was characterized by diffuse brown staining and mainly expressed in cell membrane and cytoplasm. The positive rates of B7-H1 in precancerous lesions group, benign tumor group and SCC group were 10?0% ( 1/10) , 40?0% ( 4/10) and 76?5% ( 39/51) , respec-tively. There was no significant correlation between expression of B7-H1 and clinicopathological characteristics. The B7-H1 was also ex-pressed in common epithelial origin non-squamous cell carcinoma, including basal cell carcinoma, sweat gland carcinoma, Paget?s dis-ease, adenoid cystic carcinoma and sebaceous carcinoma with positive expression rates of 81?4% ( 35/43) , 70?0% ( 7/10) , 100?0%( 3/3) , 100?0% ( 2/2) , 100?0% ( 1/1) and 76?2% ( 16/21) . No expression was observed in the non-epithelial origin bulge fibrosar-coma. Conclusion B7-H1 is involved in the carcinogenesis and development of malignant cutaneous tumor.