CAJ | 학술논문

目的：探讨细丝蛋白A（ FLNA）在肾癌中的表达情况及其与临床病理特征的关系。方法分别采用免疫组化SP法、Western blotting检测70例肾癌组织及38例癌旁组织的FLNA蛋白阳性表达率和表达水平，分析肾癌组织中FLNA蛋白表达与临床病理参数（性别、年龄、肿瘤直径、病理类型、淋巴结转移、临床分期及病理分级）的关系。结果肾癌组织FLNA蛋白阳性表达率和表达水平分别为37.1％（26／70）和0.27±0.04，均低于癌旁组织的71.1％（27／38）和0.83±0.08，差异有统计学意义（ P＜0.05）；FLNA蛋白表达与淋巴结转移、临床分期及病理分级有关（ P＜0.05）；FLNA蛋白表达与年龄、性别、肿瘤直径及病理类型均无关（ P＞0.05）。结论肾癌组织中FLNA蛋白呈低表达，且与淋巴结转移、临床分期及病理分级有关，可能在肾癌的发生发展中发挥重要作用。
목적：탐토세사단백A（ FLNA）재신암중적표체정황급기여림상병리특정적관계。방법분별채용면역조화SP법、Western blotting검측70례신암조직급38례암방조직적FLNA단백양성표체솔화표체수평，분석신암조직중FLNA단백표체여림상병리삼수（성별、년령、종류직경、병리류형、림파결전이、림상분기급병리분급）적관계。결과신암조직FLNA단백양성표체솔화표체수평분별위37.1％（26／70）화0.27±0.04，균저우암방조직적71.1％（27／38）화0.83±0.08，차이유통계학의의（ P＜0.05）；FLNA단백표체여림파결전이、림상분기급병리분급유관（ P＜0.05）；FLNA단백표체여년령、성별、종류직경급병리류형균무관（ P＞0.05）。결론신암조직중FLNA단백정저표체，차여림파결전이、림상분기급병리분급유관，가능재신암적발생발전중발휘중요작용。
Objective To investigate the expression and clinical significance of filamin A(FLNA)in renal cell carcinoma. Methods The immunohistochemistry( SP method) and Western blotting were used to analyze the positive expression rate and level of FLNA on tissue sections from 70 renal cell carcinoma tissues and 38 adjacent tissues. Then the relationships between FLNA expression and clinicopathological variables( sex, age, tumor size, histological type, lymph node metastasis, clinical stage and histological grade) were analyzed. Results The positive expression rate and level of FLNA in renal cell carcinoma tissues were 37.1%( 26/70) and 0.27 ±0.04, lower than 71.1%(27/38)and 0.83±0.08 in adjacent tissues with significant difference(P<0.05). The FLNA expression is related with lymph node metastasis, clinical stage and histological grade( P<0.05) , but not with sex, age, tumor size and histological type(P>0.05). Conclusion There was a decreased expression rate and level of FLNA protein in renal cell carcinoma tissues, and its expression was related with lymph node metastasis, clinical stage and histological grade, indicating that FLNA may play an important role in the development of renal cell carcinoma.