CAJ | 학술논문

利用磁性纳米粒子在交变磁场作用下的磁热效应，来实现对 Fe3 O4/P(NIPAAm-co-Am)复合微球温度的控制，以达到肿瘤热疗与化疗联合治疗的目的。主要研究了交变磁场作用下复合微球的磁热性能的影响因素。研究结果表明，所制备的 Fe3 O4/P (NIPAAm-co-Am)复合微球具有很好的超顺磁性，且在交变磁场作用下具有很好的磁热效应，其磁热效应可以通过调节微球的浓度、交变磁场的磁场强度和频率等因素来调控，以适应不同应用场合需求。
이용자성납미입자재교변자장작용하적자열효응，래실현대 Fe3 O4/P(NIPAAm-co-Am)복합미구온도적공제，이체도종류열료여화료연합치료적목적。주요연구료교변자장작용하복합미구적자열성능적영향인소。연구결과표명，소제비적 Fe3 O4/P (NIPAAm-co-Am)복합미구구유흔호적초순자성，차재교변자장작용하구유흔호적자열효응，기자열효응가이통과조절미구적농도、교변자장적자장강도화빈솔등인소래조공，이괄응불동응용장합수구。
Research on the magnetic thermo-sensitive composite microspheres for controlled release drug carrier was meaningful.Magnetocaloric effect was used to heat the Fe3O4/P (NIPAAm-co-Am)composite micro-spheres,and the heat generation abilities of the composited microspheres in alternation magnetic field (AMF) were investigated in the present work.Results show the resultant Fe3O4/P(NIPAAm-co-Am)composite mi-crospheres exhibite excellent superparamagnetic and high heating generation ability.The temperature of the composite microspheres was raised after exposed to AMF,which can stimulate the shrinks of P(NIPAAm-co-Am).Furthermore,the temperature raised after exposed to AMF can be adj usted by controlling the concentra-tion of composite microspheres,the magnetic intensity and the frequency of the AMF.