CAJ | 학술논문

采用同晶置换以 Zn2+代替 Mg2+合成 Mg/Zn/Al-LDHs,并将茶碱插入 LDHs 层间形成超分子复合物。通过 XRD、FT-IR、UV 和 TG-DTA 考察了Mg/Zn/Al-LDHs 和茶碱插层组装 Mg/Zn/Al-LDHs的反应条件及影响因素。结果表明,采用共沉淀法,在n(Mg)∶n(Zn)∶n(Al)∶n(茶碱)=3∶1∶1∶2、p H值=9、T=80℃、晶化12 h的条件下可获得化学组成清晰和结晶度良好的无机/有机杂化型药物插层LDHs。测试了茶碱插层 LDHs 在不同介质中的缓释性能,及其茶碱的释放量,探讨了茶碱插层LD H s的缓释机理。
채용동정치환이 Zn2+대체 Mg2+합성 Mg/Zn/Al-LDHs,병장다감삽입 LDHs 층간형성초분자복합물。통과 XRD、FT-IR、UV 화 TG-DTA 고찰료Mg/Zn/Al-LDHs 화다감삽층조장 Mg/Zn/Al-LDHs적반응조건급영향인소。결과표명,채용공침정법,재n(Mg)∶n(Zn)∶n(Al)∶n(다감)=3∶1∶1∶2、p H치=9、T=80℃、정화12 h적조건하가획득화학조성청석화결정도량호적무궤/유궤잡화형약물삽층LDHs。측시료다감삽층 LDHs 재불동개질중적완석성능,급기다감적석방량,탐토료다감삽층LD H s적완석궤리。
Mg/Zn/Al-LDHs were prepared by isomorphous substitution with Zn2+ instead of Mg2+,forming su-pramolecular composites by inserting theophylline into LDHs layer.The reaction conditions and influence fac-tors of Mg/Zn/Al-LDH and intercalated-LDHs were studied by XRD,FT-IR,UV and TG-DTA.The inorgan-ic/organic heterozygous drug intercalated-LDHs of clear chemical composition and good crystallinity were ob-tained by coprecipitation method at best condition(n(Mg)∶n(Zn)∶n(Al)=3∶1∶1∶2,pH=9,T=80 ℃, and crystallization time of 12 h).Sustained-release properties of theophylline-intercalated LDHs and calculated release quantity of theophylline were tested,and controlled-release mechanism of the theophylline-intercalated LDH was discussed.