CAJ | 학술논문

目的：探讨经方薯蓣丸对变应性鼻炎（AR）大鼠模型的疗效及对血清IgE、IL-4含量的影响。方法60只大鼠随机分为正常对照组、模型组、辛芩颗粒组、经方薯蓣丸高、中、低剂量组（3.2，1.6，0.8g/kg），每组10只。对除正常对照组外的5组大鼠采用卵清蛋白（OVA）致敏和激发进行造模，造模成功后给药，经方薯蓣丸高、中、低剂量组分别采用薯蓣丸浓缩水煎液灌胃，辛芩颗粒组给予辛芩颗粒灌胃。治疗14d后采用酶联免疫吸附试验（ELISA法）检测各组大鼠血清IgE、IL-4含量。结果造模后各组大鼠行为学评分均明显高于正常对照组（P＜0.01）；治疗后各组行为学评分及血清IgE、IL-4含量较模型组均有降低（P＜0.05）；与辛芩颗粒组相比，中剂量组血清IgE、IL-4含量明显降低，差异有统计学意义（P＜0.05）。结论经方薯蓣丸对AR大鼠模型的疗效显著，其作用机理可能与降低血清IgE、IL-4含量有关。
목적：탐토경방서여환대변응성비염（AR）대서모형적료효급대혈청IgE、IL-4함량적영향。방법60지대서수궤분위정상대조조、모형조、신금과립조、경방서여환고、중、저제량조（3.2，1.6，0.8g/kg），매조10지。대제정상대조조외적5조대서채용란청단백（OVA）치민화격발진행조모，조모성공후급약，경방서여환고、중、저제량조분별채용서여환농축수전액관위，신금과립조급여신금과립관위。치료14d후채용매련면역흡부시험（ELISA법）검측각조대서혈청IgE、IL-4함량。결과조모후각조대서행위학평분균명현고우정상대조조（P＜0.01）；치료후각조행위학평분급혈청IgE、IL-4함량교모형조균유강저（P＜0.05）；여신금과립조상비，중제량조혈청IgE、IL-4함량명현강저，차이유통계학의의（P＜0.05）。결론경방서여환대AR대서모형적료효현저，기작용궤리가능여강저혈청IgE、IL-4함량유관。
Objective Study on Shuyuwan on allergic rhinitis(AR)rat model of curative effect and the impact on the content of serum IgE and IL-4. Methods 60 rats were randomly divided into Normal control group,Model groups,Xin-Qin control group, Shuyuwan in high,medium and low-dose groups (3. 2,1. 6,0. 8g/kg),10 in each group. In addition to the normal control group,on five groups of rats were ovalbumin (OVA)sensitization and challenge for modeling. After modeling success,The party Shuyuwan for high,medium and low dose group were used respectively to condense water decoction lavage,Xin-Qin control group given particle gavage. After 14d treatment using enzyme-linked immunosorbent assay (ELISA method)detection of serum IgE and IL-4 levels in rats of each group. Results Modeled after the set of behavioral scores in rats were significantly higher than the control group (P<0. 01). After treatment the Group behavioral scoring and serum IgE,IL-4 content model group had lower(P<0. 05). Compare with Xin-Qin control group,Medium-dose group significantly lower serum IgE,IL-4 levels,the difference was statistically significant (P<0. 05). Conclusion The Shuyuwan can decrease the serum IgE and IL-4 levels in experimental rats,played against allergies and relieve symptoms of allergic rhinitis.