CAJ | 학술논문

目的：探讨血必净治疗急性胰腺炎的疗效及其对患者血清炎症因子和氧自由基的影响。方法将118例急性胰腺炎患者随机分为血必净治疗组及对照组，治疗组在对照组治疗基础上加用血必净。记录患者腹痛、腹胀缓解时间及住院天数，检测两组患者入院第1天、第7天血清C反应蛋白（CRP）、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）、超氧化物歧化酶（SOD）水平，并进行比较。结果血必净治疗组患者腹痛、腹胀缓解时间及住院天数均显著低于对照组（P<0.01），入院治疗第7天血清CRP、IL-6、TNF-α、MDA水平低于对照组（P<0.05），SOD水平显著高于对照组（P<0.01）。结论血必净可有效降低急性胰腺炎患者血清炎症因子水平，清除氧自由基，改善临床症状，缩短住院时间。
목적：탐토혈필정치료급성이선염적료효급기대환자혈청염증인자화양자유기적영향。방법장118례급성이선염환자수궤분위혈필정치료조급대조조，치료조재대조조치료기출상가용혈필정。기록환자복통、복창완해시간급주원천수，검측량조환자입원제1천、제7천혈청C반응단백（CRP）、백개소-6（IL-6）、종류배사인자-α（TNF-α）、병이철（MDA）、초양화물기화매（SOD）수평，병진행비교。결과혈필정치료조환자복통、복창완해시간급주원천수균현저저우대조조（P<0.01），입원치료제7천혈청CRP、IL-6、TNF-α、MDA수평저우대조조（P<0.05），SOD수평현저고우대조조（P<0.01）。결론혈필정가유효강저급성이선염환자혈청염증인자수평，청제양자유기，개선림상증상，축단주원시간。
Objective To explore the clinical efficiency of xuebijing on patients with acute pancreatitis and it′s effect on serum inflammatory cytokines and oxygen free radical levels. Methods One hundred and eighteen acute pancreatitis patients were randomly divided into the xuebijing treatment group and control group. Treatment group were treated with xuebijing in addition to the treatment of control group. The relief time of abdominal pain and bloating, the time of hospitalization were recorded. The serum C-reactive protein (CRP),interleukin-6(IL-6), tumor necrosis factor-α(TNF-α), malondialdehyde(MDA) and superoxide dismu-tase(SOD) levels of the 1st and 7th day were detected. Results The relief time of abdominal pain and bloating, the time of hospitalization of xuebijing in treatment group were significantly lower than that of control group(P<0.01). The serum CRP, IL-6, TNF-α, MDA were lower than that of control group(P<0.05), and SOD was significantly higher than that of control group (P<0.01). Conclusion Xuebijing can effectively reduce the serum inflammatory cytokine levels, scavenging oxygen free radicals, improve clinical symptoms, and shorten hospital stay of acute pancreatitis patients.