中国医药导刊
中國醫藥導刊
중국의약도간
CHINESE JOURNAL OF MEDICAL GUIDE
2014年
4期
553-555
,共3页
蒿艳蓉%杨姣%冯国生%陈甲信%邓珊%庞强%秦俭%陆合明%彭露杏%程金建
蒿豔蓉%楊姣%馮國生%陳甲信%鄧珊%龐彊%秦儉%陸閤明%彭露杏%程金建
호염용%양교%풍국생%진갑신%산산%방강%진검%륙합명%팽로행%정금건
DNA依赖蛋白激酶催化亚基%免疫组织化学%鼻咽癌%预后
DNA依賴蛋白激酶催化亞基%免疫組織化學%鼻嚥癌%預後
DNA의뢰단백격매최화아기%면역조직화학%비인암%예후
DNA-dependent protein kinase catalytic subunit (DNA-PKcs)%Immunohistochemistry%Nasopharyngeal cancinoma%Prognosis
目的：研究DNA-PKcs蛋白表达与鼻咽癌预后的关系。方法：收集2007年5月~2012年2月经广西壮族自治区人民医院病理学确诊为鼻咽癌且选择调强放疗的患者100例。其中13例失访。采用免疫组化SP法检测87例患者中DNA-PKcs蛋白在鼻咽癌组织中的表达,分析DNA-PKcs蛋白表达与患者近期疗效、总生存以及发生远处转移之间的关系。结果：87例患者DNA-PKcs高表达60.0%,低表达40%。DNA-PKcs的表达水平与患者的近期疗效无关(P=0.348)；但与患者生存时间呈正相关(r=0.234,P=0.048),单因素分析显示DNA-PKcs低表达者较高表达者更容易发生远处转移(P=0.001),而且生存时间更短(P=0.007)。结论：鼻咽癌组织中DNA-PKcs的表达水平与患者近期疗效无关,DNA-PKcs低表达可能作为预测鼻咽癌患者预后较差的一个指标。
目的：研究DNA-PKcs蛋白錶達與鼻嚥癌預後的關繫。方法：收集2007年5月~2012年2月經廣西壯族自治區人民醫院病理學確診為鼻嚥癌且選擇調彊放療的患者100例。其中13例失訪。採用免疫組化SP法檢測87例患者中DNA-PKcs蛋白在鼻嚥癌組織中的錶達,分析DNA-PKcs蛋白錶達與患者近期療效、總生存以及髮生遠處轉移之間的關繫。結果：87例患者DNA-PKcs高錶達60.0%,低錶達40%。DNA-PKcs的錶達水平與患者的近期療效無關(P=0.348)；但與患者生存時間呈正相關(r=0.234,P=0.048),單因素分析顯示DNA-PKcs低錶達者較高錶達者更容易髮生遠處轉移(P=0.001),而且生存時間更短(P=0.007)。結論：鼻嚥癌組織中DNA-PKcs的錶達水平與患者近期療效無關,DNA-PKcs低錶達可能作為預測鼻嚥癌患者預後較差的一箇指標。
목적：연구DNA-PKcs단백표체여비인암예후적관계。방법：수집2007년5월~2012년2월경엄서장족자치구인민의원병이학학진위비인암차선택조강방료적환자100례。기중13례실방。채용면역조화SP법검측87례환자중DNA-PKcs단백재비인암조직중적표체,분석DNA-PKcs단백표체여환자근기료효、총생존이급발생원처전이지간적관계。결과：87례환자DNA-PKcs고표체60.0%,저표체40%。DNA-PKcs적표체수평여환자적근기료효무관(P=0.348)；단여환자생존시간정정상관(r=0.234,P=0.048),단인소분석현시DNA-PKcs저표체자교고표체자경용역발생원처전이(P=0.001),이차생존시간경단(P=0.007)。결론：비인암조직중DNA-PKcs적표체수평여환자근기료효무관,DNA-PKcs저표체가능작위예측비인암환자예후교차적일개지표。
Objective:To investigate the expressions of DNA-dependent protein kinase catalytic subunit(DNA-PKcs) in nasopharyngeal cancinoma and their relationships with clinical outcome.Methods:Between May 2007 and February 2012,all 100 untreated patients with NPC,who were planned to receive IMRT at the People’s Hospital of Guangxi Autonomous Region were enrolled in this study.However,13 of 100 patients lost to follow-up.The expression of DNA-PKcs proteins in the tissue of nasopharyngeal carcinoma was detected by immunohistochemistry and then combined with all the clinical data to analyze the relationship between the expression of the proteins and prognosis of the patients.Results:The overexpression of DNA-PKcs was 60%and low expression 40%in 87 cases of patients. No significant differences were found between the expression of the proteins and short-term effect(P=0.348).Howerer,There was a significant positive correlation between the expression level of DNA-PKcsand survival time of patients(r=0.234,P=0.048). Moreover,patients with high DNA-PKcs expression had significantly better distant metastasis-free survival than patients with low levels of DNA-PKcs(P=0.001).Conclusion:There was no significant correlation between the expression level of DNA-PKcs and short-term effect. Lower expression of DNA-PKcs might have higher distant metastasis in patients with NPC.
