中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
10期
70-72
,共3页
丙泊酚%依托咪酯%地佐辛%胃肠道内窥镜%镇静
丙泊酚%依託咪酯%地佐辛%胃腸道內窺鏡%鎮靜
병박분%의탁미지%지좌신%위장도내규경%진정
Propofol%Etomidate%Dezocine%Gastrointestinal scope%Sedation
目的：比较丙泊酚和依托咪酯分别复合地佐辛用于老年人无痛胃肠镜检查的临床效能。方法：选取ASAⅠ~Ⅲ级拟行无痛胃肠镜检查的老年患者82例，按随机数字表法分为两组，每组41例。丙泊酚+地佐辛组（P组）和依托咪酯+地佐辛组（E组）。记录给药前（T0）、注药后检查前（T1）、检查开始后1 min（T2）、检查完毕（T3）、清醒时（T4）患者MAP、HR、SpO2；记录患者有无肌震颤、术中体动、呼吸抑制、苏醒后恶心呕吐、头晕等不适以及检查时间、停药后完全苏醒时间。结果：P组给药后MAP、SpO2均有下降（P<0.05），MAP在T3回升，SpO2在T2回升；E组MAP、HR各时间点均无明显差别（P>0.05），SpO2给药后开始下降（P<0.05），T2回升；T1和T2时点P组MAP明显低于E组（P<0.05）；两组停药后患者完全苏醒时间无明显差别（P>0.05）；E组出现了明显肌颤且术后恶心呕吐的例数明显高于P组（P<0.05）。结论：丙泊酚和依托咪酯分别复合地佐辛用于老年人无痛胃肠镜检查麻醉均可取得较好的效果；丙泊酚复合地佐辛具有心血管系统影响轻微，不良反应少的优点。
目的：比較丙泊酚和依託咪酯分彆複閤地佐辛用于老年人無痛胃腸鏡檢查的臨床效能。方法：選取ASAⅠ~Ⅲ級擬行無痛胃腸鏡檢查的老年患者82例，按隨機數字錶法分為兩組，每組41例。丙泊酚+地佐辛組（P組）和依託咪酯+地佐辛組（E組）。記錄給藥前（T0）、註藥後檢查前（T1）、檢查開始後1 min（T2）、檢查完畢（T3）、清醒時（T4）患者MAP、HR、SpO2；記錄患者有無肌震顫、術中體動、呼吸抑製、囌醒後噁心嘔吐、頭暈等不適以及檢查時間、停藥後完全囌醒時間。結果：P組給藥後MAP、SpO2均有下降（P<0.05），MAP在T3迴升，SpO2在T2迴升；E組MAP、HR各時間點均無明顯差彆（P>0.05），SpO2給藥後開始下降（P<0.05），T2迴升；T1和T2時點P組MAP明顯低于E組（P<0.05）；兩組停藥後患者完全囌醒時間無明顯差彆（P>0.05）；E組齣現瞭明顯肌顫且術後噁心嘔吐的例數明顯高于P組（P<0.05）。結論：丙泊酚和依託咪酯分彆複閤地佐辛用于老年人無痛胃腸鏡檢查痳醉均可取得較好的效果；丙泊酚複閤地佐辛具有心血管繫統影響輕微，不良反應少的優點。
목적：비교병박분화의탁미지분별복합지좌신용우노년인무통위장경검사적림상효능。방법：선취ASAⅠ~Ⅲ급의행무통위장경검사적노년환자82례，안수궤수자표법분위량조，매조41례。병박분+지좌신조（P조）화의탁미지+지좌신조（E조）。기록급약전（T0）、주약후검사전（T1）、검사개시후1 min（T2）、검사완필（T3）、청성시（T4）환자MAP、HR、SpO2；기록환자유무기진전、술중체동、호흡억제、소성후악심구토、두훈등불괄이급검사시간、정약후완전소성시간。결과：P조급약후MAP、SpO2균유하강（P<0.05），MAP재T3회승，SpO2재T2회승；E조MAP、HR각시간점균무명현차별（P>0.05），SpO2급약후개시하강（P<0.05），T2회승；T1화T2시점P조MAP명현저우E조（P<0.05）；량조정약후환자완전소성시간무명현차별（P>0.05）；E조출현료명현기전차술후악심구토적례수명현고우P조（P<0.05）。결론：병박분화의탁미지분별복합지좌신용우노년인무통위장경검사마취균가취득교호적효과；병박분복합지좌신구유심혈관계통영향경미，불량반응소적우점。
Objective:To compare effects of Propofol and Etomidate combined with Dezocine respectively for sedated gastrointestinal scope in elderly patients. Method:82 elderly patients with ASAⅠ-Ⅲwere scheduled for sedated gastrointestinal scope,were randomly divided into two groups with random number table:Propofol+Dezocine group(P group) and Etomidate+Dezocine group(E group),each group had 41 cases. The MAP,HR and SpO2 were recorded before drug injection(T0),before examination(T1),1 minute after examination(T2),end examination(T3)and consciousness recovery (T4). The incidence of myoclonus,body movements,respiratory depression,nausea,vomit,dizziness and examination time,consciousness recovery time after drug withdrawal were recorded during examination. Result:In the group P,the MAP, SpO2 significantly decreased after drug injection(P<0.05)and rised in T3,T2 in turn. In the group E,the MAP,HR were insignificant difference between each time point(P>0.05)and the SpO2 was significant decreased after drug injection(P<0.05) and rised in T2. In T1 and T2 the MAP was significant lower in group P than that in group E(P<0.05). There was insignificant difference between the two groups in consciousness recovery time after drug withdrawal(P>0.05). Compared with group P,the incidence of myoclonus,nausea,vomit were significant higher than that in group E(P<0.05). Conclusion:Both propofol and etomidate combined with dezocine for sedated gastrointestinal scope is safe and effective in elderly patients,but propofol combined with dezocine has the advantage of slight effects on the cardiovascular system and less adverse reactions.
