CAJ | 학술논문

背景长期以来硫化氢(hydrogen sulfide,H2S)都被认为是造成环境污染的有毒气体.后来研究发现,哺乳动物体内的H2S是一种具有生理调节作用的内源性气体介质,具有多种生物学功能.H2S与一氧化氮(nitric oxide,NO)、一氧化碳(carbon monoxide,CO)共同组成了气体信号分子家系.过去十年里,有关H2S在生理和病理过程中的作用,尤其是在中枢神经系统和心血管系统中的作用,进行了大量研究.目的阐释当前H2S在中枢神经系统的生理及保护作用研究进展.内容简要描述H2S在中枢神经系统的合成、调节以及生理功能 ;重点介绍H2S中枢神经系统保护作用的可能机制.趋向通过阐述H2S在中枢神经系统的生理及保护作用机制,为H2S用于神经系统相关疾病的治疗提供新的思路.
배경 장기이래류화경(hydrogen sulfide,H2S)도피인위시조성배경오염적유독기체.후래연구발현,포유동물체내적H2S시일충구유생리조절작용적내원성기체개질,구유다충생물학공능.H2S여일양화담(nitric oxide,NO)、일양화탄(carbon monoxide,CO)공동조성료기체신호분자가계.과거십년리,유관H2S재생리화병리과정중적작용,우기시재중추신경계통화심혈관계통중적작용,진행료대량연구.목적 천석당전H2S재중추신경계통적생리급보호작용연구진전.내용 간요묘술H2S재중추신경계통적합성、조절이급생리공능 ;중점개소H2S중추신경계통보호작용적가능궤제.추향 통과천술H2S재중추신경계통적생리급보호작용궤제,위H2S용우신경계통상관질병적치료제공신적사로.
Background Hydrogen sulfide (H2S) was known to be a toxic gas and an environmental hazard for many decades.However,it is now recognized that H2S may serve as a gaseous mediator,which is endogenously produced to influence biological functions in mammalian.Together with nitric oxide and carbon monoxide,they form gasotransmitter family.The past decade has seen an exponential growth of scientific interest in the physiological and pathological significance of H2S especially with respect to its role in the central nervous system (CNS) and the cardiovascular system.Objective This article presents an overview of current knowledge of H2S in cerebral protection and mechanisms.Content This review concisely outlines the H2S generation and regulation in the CNS,aud the possible mechanisms of H2S in cerebral protection.Trend Through explaining the physiology and mechanisms of H2S in cerebral protection,it would be helpful to provide a new therapeutic target for neurological disorders.