中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2013年
19期
50-52
,共3页
丹参多酚酸盐%不稳定型心绞痛%系统评价%有效性%安全性
丹參多酚痠鹽%不穩定型心絞痛%繫統評價%有效性%安全性
단삼다분산염%불은정형심교통%계통평개%유효성%안전성
Salvianolate%Unstable angina pectoris%Systematic evaluation%Efficacy%Safety
目的系统评价丹参多酚酸盐治疗不稳定型心绞痛的有效性和安全性，为临床决策提供科学依据。方法全面检索文献，并进行筛选。对纳入文献进行质量评价之后，采用RevMan5.0软件对同质研究进行Meta分析，对具临床异质性研究进行定性评价，潜在的发表偏倚采用“倒漏斗”图示分析。结果共纳入20个研究，1547个病例。分析结果显示：在常规西医药治疗基础上辅以丹参多酚酸盐，与只采用西医药治疗相比，在临床有效性和心电图改善方面RR及95%CI分别为1.33（1.25，1.41）、1.36（1.27,1.45），P值均＜0.001，有统计学意义；而与其他中药注射剂相比，临床有效性和心电图改善均不确切。使用丹参多酚酸盐的主要不良反应为头痛、头晕，但基本能耐受。结论丹参多酚酸盐对不稳定型心绞痛有一定的辅助治疗效果，且不良反应较少、较轻。
目的繫統評價丹參多酚痠鹽治療不穩定型心絞痛的有效性和安全性，為臨床決策提供科學依據。方法全麵檢索文獻，併進行篩選。對納入文獻進行質量評價之後，採用RevMan5.0軟件對同質研究進行Meta分析，對具臨床異質性研究進行定性評價，潛在的髮錶偏倚採用“倒漏鬥”圖示分析。結果共納入20箇研究，1547箇病例。分析結果顯示：在常規西醫藥治療基礎上輔以丹參多酚痠鹽，與隻採用西醫藥治療相比，在臨床有效性和心電圖改善方麵RR及95%CI分彆為1.33（1.25，1.41）、1.36（1.27,1.45），P值均＜0.001，有統計學意義；而與其他中藥註射劑相比，臨床有效性和心電圖改善均不確切。使用丹參多酚痠鹽的主要不良反應為頭痛、頭暈，但基本能耐受。結論丹參多酚痠鹽對不穩定型心絞痛有一定的輔助治療效果，且不良反應較少、較輕。
목적계통평개단삼다분산염치료불은정형심교통적유효성화안전성，위림상결책제공과학의거。방법전면검색문헌，병진행사선。대납입문헌진행질량평개지후，채용RevMan5.0연건대동질연구진행Meta분석，대구림상이질성연구진행정성평개，잠재적발표편의채용“도루두”도시분석。결과공납입20개연구，1547개병례。분석결과현시：재상규서의약치료기출상보이단삼다분산염，여지채용서의약치료상비，재림상유효성화심전도개선방면RR급95%CI분별위1.33（1.25，1.41）、1.36（1.27,1.45），P치균＜0.001，유통계학의의；이여기타중약주사제상비，림상유효성화심전도개선균불학절。사용단삼다분산염적주요불량반응위두통、두훈，단기본능내수。결론단삼다분산염대불은정형심교통유일정적보조치료효과，차불량반응교소、교경。
Objective To evaluate systematically the efficacy and the safety of Salvianolate for unstable angina pectoris, from which to provide scientific proofs for clinical decision making. Methods We retrieved and selected publications. We evaluated the quality of eligible studies. And then Meta-analyses were performed for homogeneous studies by RevMan 5.0 software. If clinical heterogeneity existed among the studies, descriptive analysis was conducted. The potential publication-bias were analyzed by funnel plot analysis. Results A total of 20 papers and 1547 cases were included in the study.The analysis indicated that compared supplementing by Salvianolate on the basis of common drug with only using common drug, both in the clinical efficacy and the improvement of electrocardiogram,RRs and 95%CI were 1.33(1.25,1.41) and 1.36(1.27,1.45)respectively, and P values were less than 0.001 which have statistical significance. Compared to other traditional Chinese medicine injections, there were no clear differences both in the clinical efficacy and the improvement of electrocardiogram.Adverse reactions of Salvianolate were mainly headache and dizzy, which could be basically endured. Conclusion The preliminary studies have shown the positive clinical effect of Salvianolate in treating unstable angina pectoris,and the adverse reactions were light and few.
