CAJ | 학술논문

　　目的研究EGFR和C-erbB-2在水泡状胎块（包括完全性和部分性水泡状胎块，CHM和PHM）中的表达情况，探讨其在水泡状胎块诊断及预后中的意义。方法应用免疫组织化学方法检测EGFR和C-erbB-2在12例正常早孕流产绒毛、24例PHM及33例CHM中的表达。结果 EGFR在正常组、PHM组及CHM组中的阳性表达分别为25.00%、50.00%和81.82%；C-erbB-2在正常组、PHM组及CHM组中的阳性表达分别为0.00%、50.00%和72.73%；EGFR和C-erbB-2在CHM中的表达均明显高于正常组（P＜0.05），而在PHM组与正常组及CHM与PHM组间差异均不显著（P＞0.05）。结论检测水泡状胎块中EGFR和C-erbB-2蛋白的表达有助于HM的诊断及监测预后。
　　목적연구EGFR화C-erbB-2재수포상태괴（포괄완전성화부분성수포상태괴，CHM화PHM）중적표체정황，탐토기재수포상태괴진단급예후중적의의。방법응용면역조직화학방법검측EGFR화C-erbB-2재12례정상조잉유산융모、24례PHM급33례CHM중적표체。결과 EGFR재정상조、PHM조급CHM조중적양성표체분별위25.00%、50.00%화81.82%；C-erbB-2재정상조、PHM조급CHM조중적양성표체분별위0.00%、50.00%화72.73%；EGFR화C-erbB-2재CHM중적표체균명현고우정상조（P＜0.05），이재PHM조여정상조급CHM여PHM조간차이균불현저（P＞0.05）。결론검측수포상태괴중EGFR화C-erbB-2단백적표체유조우HM적진단급감측예후。
Purpose To investigate the expression and significance of EGFR and C-erbB-2 in hydatidiform mole, including of complete hydatidiform mole(CHM) and partial hydatidiform mole(PHM). Methods The expression of EGFR and C-erbB-2 were detected by immunohistochemical technique in 12 cases of normal chorionic villi ,24 cases of PHM and 33 cases of CHM. Results The positive expression of EGFR was25.00%, 50.00%and 81.82%, respectively. The positive expression of C-erbB-2 was 0.00%, 50.00%and 72.73%, respectively. The rate of EGFR and C-erbB-2 expression was significantly higher than the normal cases(P<0.05),but the difference of PHM and CHM did not reach significance(P>0.05).Conclusion The detection of EGFR and C-erbB-2 protein expression in hydatidiform mole is helpful to a better understanding of the biological behavior of hydatidiform mole with diagnosis prognostic evaluation.