CAJ | 학술논문

　　目的研究肌钙蛋白I（cTnI）、肌酸激酶同工酶（CK-MB）、肌红蛋白（Mb）浓度监测在诊断急性心肌梗死（AMI）中的作用。方法采用电化学发光法检测45例急性心肌梗死患者在胸痛发作后五个时间点的cTnI、CK-MB以及Mb血清浓度，以45例健康体检者作为对照，并对上述数据进行统计学分析，研究其诊断价值。结果 AMI患者在胸痛发作后所有检查时间内的血清cTnI、CK-MB浓度均高于对照组，差异有显著意义，血清Mb浓度在患者胸痛发作后0-6h、12h、24h均高于对照组，而且在诊断急性心肌梗死的特异度、灵敏度、准确度、阳性预测值和阴性预测值方面，cTnI和CK-MB均明显高于Mb。结论同时检测cTnI和CK-MB两个血清标记物，对于早期诊断AMI具有重要意义，有助于改善患者预后。
　　목적연구기개단백I（cTnI）、기산격매동공매（CK-MB）、기홍단백（Mb）농도감측재진단급성심기경사（AMI）중적작용。방법채용전화학발광법검측45례급성심기경사환자재흉통발작후오개시간점적cTnI、CK-MB이급Mb혈청농도，이45례건강체검자작위대조，병대상술수거진행통계학분석，연구기진단개치。결과 AMI환자재흉통발작후소유검사시간내적혈청cTnI、CK-MB농도균고우대조조，차이유현저의의，혈청Mb농도재환자흉통발작후0-6h、12h、24h균고우대조조，이차재진단급성심기경사적특이도、령민도、준학도、양성예측치화음성예측치방면，cTnI화CK-MB균명현고우Mb。결론동시검측cTnI화CK-MB량개혈청표기물，대우조기진단AMI구유중요의의，유조우개선환자예후。
Objective Investigate the role of monitoring serum concentration of cardiac troponin I (cTnI), creative kinase isoenzyme MB (CK-MB) and myoglobin (Mb) on the diagnosis of Acute Myocardial Infarction (AMI).Methods Detect serum concentration of cTnI, CK-MB and Mb from 45 cases of AMI patients using electrochemical luminescence at five different timepoints. And another 45 cases of healthy controls were examined. Analyze cTnI, CK-MB and Mb concentration by variance analysis and ROC curve, and discuss the diagnostic value .Results The serum concentrations of cTnI, CK-MB in AMI patients were significantly higher than control at all 5 different timepoints after onset of chest pain. The serum concentration of Mb in AMI patients was significantly higher than control at 0-6h, 12h, 24h after chest pain. And specificity, sensitivity, accuracy, positive predictive value (PPV) and negative predictive value (NPV) of cTnI, CK-MB were significantly higher than Mb on the diagnosis of AMI. Conclusion Combined detecting serum concentration dynamic changes of cTnI and CK-MB had significant value and high accuracy on early diagnosis of AMI, which help to improve the prognosis of patients.