CAJ | 학술논문

目的：使用1．5T磁共振仪观察早期帕金森病黑质致密部FA 值的变化特点。方法：对20例早期帕金森病（PD）患者及28例性别、年龄与PD组相匹配的健康志愿者行 MR T2 WI和DTI 扫描。在T2 WI 和DTI 融合图像上手工勾勒黑质致密部内各兴趣区的范围，测量并记录黑质头、体、尾部及内外侧的 FA 值并进行统计学分析。结果：早期帕金森病患者黑质致密部的头、体及尾部的FA值均较正常对照组明显降低，以头部更明显（分别为0．201±0．030和0．254±0．050，P＜0．05）；两组在黑质内、外侧区的 FA 值差异亦均有统计学意义（P＜0．05）。当黑质致密部头部 FA 值小于0．224，高度提示帕金森病可能。结论：黑质致密部的头部FA值降低对早期帕金森病的诊断有一定价值。
목적：사용1．5T자공진의관찰조기파금삼병흑질치밀부FA 치적변화특점。방법：대20례조기파금삼병（PD）환자급28례성별、년령여PD조상필배적건강지원자행 MR T2 WI화DTI 소묘。재T2 WI 화DTI 융합도상상수공구륵흑질치밀부내각흥취구적범위，측량병기록흑질두、체、미부급내외측적 FA 치병진행통계학분석。결과：조기파금삼병환자흑질치밀부적두、체급미부적FA치균교정상대조조명현강저，이두부경명현（분별위0．201±0．030화0．254±0．050，P＜0．05）；량조재흑질내、외측구적 FA 치차이역균유통계학의의（P＜0．05）。당흑질치밀부두부 FA 치소우0．224，고도제시파금삼병가능。결론：흑질치밀부적두부FA치강저대조기파금삼병적진단유일정개치。
Objective:To observe the characteristic changes of FA value of substantia nigra pars compacta in early Parkinson′s disease using 1 .5T MR scanner.Methods:20 patients with early Parkinson′s disease and 28 cases of gender and age-matched normal volunteers had MR scanning with T2 WI sequence and DTI.Taking T2 WI as reference,hand-sketched region of interest (ROI)including head,body,tail as well as internal and external areas in substantia nigra were done,their FA values were measured.Statistical analysis was calculated.Results:FA values of substantia nigra pars compacta decreased significantly in early Parkinson′s disease;The FA values of the head,body,tail of substantia nigra pars compacta were lower than those of the normal control group significantly,with the head as the most obvious,which was 0.201 ±0.030 and 0.254±0.050 respectively,P<0.05.When FA value of the head of substantia nigra pars compacta was less than 0.224, Parkinson′s disease should be highly suspected.Conclusion:Lowering of FA values of the head of substantia nigra pars com-pacta shows a certain value in the early diagnosis of Parkinson′s disease.